Dose–response relationship between periodontal inflamed surface area and HbA1c in type 2 Diabetics

Nesse, Willem; Linde, Annemiek; Abbas, Frank; Spijkervet, Frederik; Dijkstra, Pieter U.; Brabander, Eric Carl de; Gerstenbluth, Izzy; Vissink, Arjan

doi:10.1111/j.1600-051x.2009.01377.x

Cited by 105 publications

(107 citation statements)

References 35 publications

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“…Periodontitis severity was operationalized using a variety of methods (number of sites with PD >4, >5 and >6 mm, number of sites with CA loss >3, >4, >5 and >6 mm, mean PD, mean CA loss and percentage of sites with BOP anywhere in the dentition) all currently used to study the association between periodontitis and other diseases [25][26][27] . To facilitate calculation a freely accessible spreadsheet (www.parsprototo.info; Microsoft Excel 2003 spreadsheet for Windows) was used online.…”

Section: Methodsmentioning

confidence: 99%

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Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

Susanto

Nesse

Kertia

et al. 2013

Journal of Periodontology

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Background: Patients with rheumatoid arthritis (RA) may have more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA.Methods: A full‐mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age‐, sex‐, and smoking‐matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high‐sensitivity C‐reactive protein (hsCRP), rheumatoid factor, and anti‐citrullinated protein antibodies were measured. Differences in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses.Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti‐inflammatory drugs, whereas none of the controls used such drugs.Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.

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Section: Methodsmentioning

confidence: 99%

“…PISA quantifies the surface area of inflamed periodontal tissue in square mm. PISA is a measure of inflammatory burden posed by periodontitis 26,28 .…”

Section: Methodsmentioning

confidence: 99%

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

Susanto

Nesse

Kertia

et al. 2013

Journal of Periodontology

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“…Es importante hacer notar que estos pacientes presentaban un deterioro periodontal de tal magnitud que varios dientes ya estaban fuera del alcance terapéutico. mejoraría la calidad de vida de los diabéticos; permitiendo alcanzar y mantener un adecuado control metabólico (15)(16)(17)(18)(19)(20)(21) , con todas las implicancias médicas que eso conlleva (22,23) . Tradicionalmente, la atención odontológica del diabético se ha pospuesto hasta que el médico certifique que el paciente esté metabólicamente compensado; dando, a veces, alguna sugerencia respecto del uso de anestesia o antibioterapia.…”

Section: Resultsunclassified

Respuesta al tratamiento periodontal de diabéticos tipo 2 con mal control metabólico y obesos intolerantes a la glucosa, con periodontitis severa

Correa

Quintanilla

2011

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

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Respuesta al tratamiento periodontal de diabéticos tipo 2 con mal control metabólico y obesos intolerantes a la glucosa, con periodontitis severa Impact of the periodontal therapy in both clinical and metabolic parameters in type 2 diabetic and prediabetic obese patients with severe periodontitis RESUMENDiabetes Mellitus (DM) es un factor de riesgo para periodontitis, a su vez, el control metabólico de los diabéticos se dificulta por la presencia de la infección periodontal, aumentando el riesgo de complicaciones crónicas y eventualmente, la mortalidad por diabetes. Ambas enfermedades se relacionan porque los mediadores de inflamación generados en la infección periodontal y la translocación de bacterias de la cavidad oral a la circulación sistémica, podrían actuar como agravantes de la insulino resistencia y deteriorar el control glicémico. Es evidente que el tratamiento oportuno de la periodontitis mejoraría la calidad de vida de los diabéticos; ayudándolos a alcanzar y mantener un adecuado control metabólico. El presente estudio evaluó el impacto de un protocolo de terapia periodontal en parámetros clínicos y metabólicos de pacientes DM2 y obesos prediabéticos, con el fin de contribuir a la inclusión de los diabéticos descompensados y prediabéticos en tratamientos periodontales exitosos, sin aumentar su riesgo médico. Se seleccionó a 9 individuos con DM2 descompensados y 7 obesos intolerantes a la glucosa, todos con Periodontitis Crónica Generalizada Severa.Los pacientes fueron sometidos a tratamiento periodontal, sin modificar las indicaciones médicas, de acuerdo a un protocolo diseñado por nosotros. Los diabéticos mostraron una leve disminución en la HbA1c a los 6 meses de realizado el tratamiento periodontal, no se registraron complicaciones, ni perdieron su condición de pacientes ambulatorios. La respuesta al tratamiento periodontal, fue similar en ambos grupos, con mejoría en todos los parámetros clínicos. Aunque los resultados obtenidos no son estadísticamente significativos, son muy promisorios. Rev. Clin. Periodoncia Implantol. Rehabil. Oral Vol. 4(2); 50-53, 2011.Palabras clave: Periodontitis, diabetes, obesidad, control metabólico. ABSTRACTDiabetes Mellitus (DM) is a risk factor for periodontitis, at the same time, the metabolic control of diabetic patients gets more difficult due to the presence of periodontal infection, increasing the risk of chronic complications and possibly, death by diabetes. It is recognized that both diseases are related because the inflammation factors generated by the periodontitis as well as the oral cavity bacteria in the systemic circulation, may act as aggravating factor for insulin resistance and worsen the glycemic control. It is clear that an opportune treatment of PD would improve the quality of life and the metabolic control of diabetic patients.The objectives of the current paper are to evaluate the impact of the periodontal therapy in both clinical and metabolic parameters in type 2 diabetic and prediabetic obese patients and to demonstrate that uncontrolled dia...

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“…14 Determination of the systemic inflammatory burden The classification reported by Hujoel 11 measures the total attachment loss surface area. This classification was modified to obtain a classification system regarding the periodontally inflamed surface area by Nesse 12 The modified version of the classification 12 was used to calculate the periodontally inflamed surface area (PISA) and periodontally epithelial surface area (PESA) using PD, CAL and BOP.…”

Section: Clinical Periodontal Parametersmentioning

confidence: 99%

“…11,12 A measurement and classification system developed by Hujoel 11 and modified by Nesse 12 was used for related periodontitis with systemic diseases in recent years. [12][13][14] From this point of view, this study was aimed to test the hypothesis whether periodontitis related systemic inflammatory burden, measured by a scale using clinical periodontal parameters, have a correlation with the future cardiovascular events using Framingham Risk Score (FRS). Patients who undergo for coronary angiography with suspicion of CAD between the ages 30 and 75 were included.…”

Section: Introductionmentioning

confidence: 99%

Is there a correlation between the periodontitis-related systemic inflammatory burden and future cardiovascular events’ risk? A preliminary report

Ay¹,

Temelli²,

Aksoy³

et al. 2017

Yeditepe J Dent

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Dose–response relationship between periodontal inflamed surface area and HbA1c in type 2 Diabetics

Abstract: On a group level, there is a dose-response relationship between PISA and HbA1c in type 2 diabetics. This might be an indication of a causal relationship between type 2 diabetes and periodontitis.

Cited by 105 publications

References 35 publications

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

Respuesta al tratamiento periodontal de diabéticos tipo 2 con mal control metabólico y obesos intolerantes a la glucosa, con periodontitis severa

Is there a correlation between the periodontitis-related systemic inflammatory burden and future cardiovascular events’ risk? A preliminary report

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