Dose Response Study of Atopy Patch Test in Children with Atopic Eczema

Niggemann

et al. 2006

Allergy

Self Cite

212

130

A number of scientific reports have been published on patch tests with protein allergens performed on patients with atopic eczema (AE). Evaluation of eczematous skin lesions with an atopy patch test (APT) can be used as a diagnostic tool in characterizing patients with aeroallergen- and food-triggered AE. Indications for testing with APT, choice of allergens (aeroallergens and foods), test materials and technique, including present knowledge on sensitivity and specificity, are reviewed on the basis of available literature. This position paper also points out the need for future research on the clinical use of the APT.

Section: Apt Techniquementioning

confidence: 99%

Section: Concentrationsmentioning

confidence: 99%

EAACI/GA²LEN Position paper: Present status of the atopy patch test*

Turjanmaa

Niggemann

et al. 2006

Allergy

Self Cite

212

130

“…We performed several studies to standardize the methods of APT on nonabraded skin and subsequently defined the relationship to clinical covariates. With the developed methods [20,21], significant correlations of APT result, and patients' histories were obtained in several studies [22][23][24]. The results of these studies sustain the concept of atopic (extrinsic/allergic) versus nonatopic (intrinsic) eczema with a heterogeneity of disease subgroups as in bronchial asthma and rhinoconjunctivitis.…”

mentioning

confidence: 66%

Allergen-specific Immunotherapy in Atopic Eczema

Curr Allergy Asthma Rep

Forer

Ring

2011

Aeroallergens are relevant eliciting factors of allergic rhinoconjunctivitis and bronchial asthma but also of atopic eczema. The use of allergen-specific immunotherapy as in respiratory atopic diseases is controversial in patients with atopic eczema, but refined diagnostic methods to characterize subgroups of patients with relevant allergies and the results of smaller controlled studies give rise to new approaches in this field. This article reviews the theoretical problems and practical results associated with allergen-specific immunotherapy in atopic eczema.

“…In 30 children and adolescents 14 years old or younger with AE enrolled in a double-blind dose-response multicenter study,[58] a lower frequency of positive APT reactions compared with adults was seen for D. pteronyssinus (34% vs 41% in adults) and cat dander (12% vs 17%). For D. pteronyssinus and grass pollen, lower allergen doses for APT seem possible in children because maximal response rates were obtained for these allergens with 3000 PNU/g, half of the adult allergen concentration.…”

Section: Methodological Studiesmentioning

confidence: 99%

Immunoglobulin E-Mediated Allergy Plays a Role in Atopic Eczema as Shown in the Atopy Patch Test

World Allergy Organization Journal

Ring

2008

Although the pathophysiology of immunoglobulin E (IgE)-mediated allergic rhinoconjunctivitis and bronchial asthma is rather well established, the role of allergy in atopic eczema (AE) is still controversial. By a technique called atopy patch test, aeroallergens like house dust mite, animal dander, or pollen were proven as relevant trigger factors in a subgroup of patients with AE. The atopy patch test is an epicutaneous patch test with such allergens known to elicit IgE-mediated reactions, and used for the evaluation of eczematous skin reactions. In a series of single-center and multicenter studies, a method was developed, standardized, and compared with other diagnostic techniques (radioallergosorbent test, skin prick test) in AE patients. With regard to clinical history, the most specific results were obtained with the atopy patch test (allergen-dependent, 69%-92%), whereas sensitivity was higher for skin prick test (range, 69%-82%) and specific IgE (range, 65%-94%). The characterization of a patient subgroup with relevant IgE-mediated allergy may lead to more efficient avoidance and eventually even specific immunotherapy strategies in the management of AE.