Dosimetric Characterization of an Inorganic Optical Fiber Sensor for External Beam Radiation Therapy

Alharbi, Majed; Gillespie, Sean; Woulfe, Peter; McCavana, Patrick; O'Keeffe, Sinéad; Foley, Mark

doi:10.1109/jsen.2018.2885409

Cited by 25 publications

(19 citation statements)

References 22 publications

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“…As expected, the detector provides an optical signal that is almost independent of dose rate. Indeed, the maximum standard deviation of the signal from the average value is as low as 0.15%, which is a very significant outcome when compared to that obtained with other detectors [see, e.g., ]. This result shows that ISD can be successfully used at a low as well as a high dose rate, as it is important for a broad range of radiotherapies.…”

Section: Resultsmentioning

confidence: 70%

High spatial resolution inorganic scintillator detector for high‐energy X‐ray beam at small field irradiation

et al. 2020

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Purpose Small field dosimetry for radiotherapy is one of the major challenges due to the size of most dosimeters, for example, sufficient spatial resolution, accurate dose distribution and energy dependency of the detector. In this context, the purpose of this research is to develop a small size scintillating detector targeting small field dosimetry and compare its performance with other commercial detectors. Method An inorganic scintillator detector (ISD) of about 200 µm outer diameter was developed and tested through different small field dosimetric characterizations under high‐energy photons (6 and 15 MV) delivered by an Elekta Linear Accelerator (LINAC). Percentage depth dose (PDD) and beam profile measurements were compared using dosimeters from PTW namely, microdiamond and PinPoint three‐dimensional (PP3D) detector. A background fiber method has been considered to quantitate and eliminate the minimal Cerenkov effect from the total optical signal magnitude. Measurements were performed inside a water phantom under IAEA Technical Reports Series recommendations (IAEA TRS 381 and TRS 483). Results Small fields ranging from 3 × 3 cm2, down to 0.5 × 0.5 cm2 were sequentially measured using the ISD and commercial dosimeters, and a good agreement was obtained among all measurements. The result also shows that, scintillating detector has good repeatability and reproducibility of the output signal with maximum deviation of 0.26% and 0.5% respectively. The Full Width Half Maximum (FWHM) was measured 0.55 cm for the smallest available square size field of 0.5 × 0.5 cm2, where the discrepancy of 0.05 cm is due to the scattering effects inside the water and convolution effect between field and detector geometries. Percentage depth dose factor dependence variation with water depth exhibits nearly the same behavior for all tested detectors. The ISD allows to perform dose measurements at a very high accuracy from low (50 cGy/min) to high dose rates (800 cGy/min) and was found to be independent of dose rate variation. The detection system also showed an excellent linearity with dose; hence, calibration was easily achieved. Conclusions The developed detector can be used to accurately measure the delivered dose at small fields during the treatment of small volume tumors. The author's measurement shows that despite using a nonwater‐equivalent detector, the detector can be a powerful candidate for beam characterization and quality assurance in, for example, radiosurgery, Intensity‐Modulated Radiotherapy (IMRT), and brachytherapy. Our detector can provide real‐time dose measurement and good spatial resolution with immediate readout, simplicity, flexibility, and robustness.

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Section: Resultsmentioning

confidence: 70%

High spatial resolution inorganic scintillator detector for high‐energy X‐ray beam at small field irradiation

et al. 2020

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“…Angular dependence was also constantly mentioned in the research concerning IOSFDs [ 19 , 59 , 89 , 90 ]. The angular dependence arises from the geometrical asymmetry of the scintillator material in the sensor tip.…”

Section: Challenges Of Iosfd For Rtd Applicationmentioning

confidence: 99%

“…11 ) have different characteristics [ 59 ]. IOSFDs with cylindrical sensor tips normally exhibit great axial angular independence and noticeable azimuth angular dependence as shown by Qin et al [ 19 ] and Alharbi et al [ 90 ]. A solution to this issue was suggested from the aspect of geometry [ 59 ].…”

Section: Challenges Of Iosfd For Rtd Applicationmentioning

confidence: 99%

Advances on inorganic scintillator-based optic fiber dosimeters

Ding

Wang³

et al. 2020

EJNMMI Phys

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This article presents a new perspective on the development of inorganic scintillator-based fiber dosimeters (IOSFDs) for medical radiotherapy dosimetry (RTD) focusing on real-time in vivo dosimetry. The scintillator-based optical fiber dosimeters (SFD) are compact, free of electromagnetic interference, radiation-resistant, and robust. They have shown great potential for real-time in vivo RTD. Compared with organic scintillators (OSs), inorganic scintillators (IOSs) have larger X-ray absorption and higher light output. Variable IOSs with maximum emission peaks in the red part of the spectrum offer convenient stem effect removal. This article outlines the main advantages and disadvantages of utilizing IOSs for SFD fabrication. IOSFDs with different configurations are presented, and their use for dosimetry in X-ray RT, brachytherapy (BT), proton therapy (PT), and boron neutron capture therapy (BNCT) is reviewed. Challenges including the percentage depth dose (PDD) deviation from the standard ion chamber (IC) measurement, the angular dependence, and the Cherenkov effect are discussed in detail; methods to overcome these problems are also presented.

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“…Fiber based scintillating dosimetry system that consists of scintillating materials coupled to the optical fiber apex has already been used in different high energy radiation measurements. [20][21][22][23] The scintillator-based detector was proposed by several research groups and can be useful to measure the step dose gradient nearby the tumor in the case of BT treatment 15,[24][25][26] Scintillators used in those dosimeters can be organic or inorganic. These reduced size detectors can mitigate the issue of volume averaging effect and can facilitate the accurate dose measurement in the tumor region and identify the treatment error.…”

Section: Introductionmentioning

confidence: 99%

High resolution small‐scale inorganic scintillator detector: HDR brachytherapy application

et al. 2021

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Purpose: Brachytherapy (BT) deals with high gradient internal dose irradiation made up of a complex system where the source is placed nearby the tumor to destroy cancerous cells. A primary concern of clinical safety in BT is quality assurance to ensure the best matches between the delivered and prescribed doses targeting small volume tumors and sparing surrounding healthy tissues. Hence, the purpose of this study is to evaluate the performance of a point size inorganic scintillator detector (ISD) in terms of high dose rate brachytherapy (HDR-BT) treatment. Methods: A prototype of the dose verification system has been developed based on scintillating dosimetry to measure a high dose rate while using an 192 Ir BT source. The associated dose rate is measured in photons/s employing a highly sensitive photon counter (design data: 20 photons/s). Dose measurement was performed as a function of source-to-detector distance according to TG43U1 recommendations. Overall measurements were carried out inside water phantoms keeping the ISD along the BT needle; a minimum of 0.1 cm distance was maintained between each measurement point. The planned dwell times were measured accurately from the difference of two adjacent times of transit. The ISD system performances were also evaluated in terms of dose linearity, energy dependency, scintillation stability, signal-to-noise ratio (SNR), and signal-to-background ratio (SBR). Finally, a comparison was presented between the ISD measurements and results obtained from TG43 reference dataset. Results: The detection efficiency of the ISD was verified by measuring the planned dwell times at different dwell positions. Measurements demonstrated that the ISD has a perfectly linear behavior with dose rate (R 2 = 1) and shows high SNR (>35) and SBR (>36) values even at the lowest dose rate investigated at around 10 cm from the source. Standard deviation (1σ) remains within 0.03% of signal magnitude, and less than 0.01% STEM signal was monitored at 0.1 cm source-to-detector distance. Stability of 0.54% is achieved, and afterglow stays less than 1% of the total signal in all the irradiations. Excellent symmetrical behavior of the dose rate regarding source position was observed at different radiation planes. Finally, a comparison with TG-43 reference dataset shows that corrected measurements agreed with simulation data within 1.2% and 1.3%, and valid for the source-to-detector distance greater than 0.25 cm. Conclusion:The proposed ISD in this study anticipated that the system could be promoted to validate with further clinical investigations. It allows an appropriate dose verification with dwell time estimation during source tracking and suitable dose measurement with a high spatial resolution both nearby (high dose gradient) and far (low dose gradient) from the source position.

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Dosimetric Characterization of an Inorganic Optical Fiber Sensor for External Beam Radiation Therapy

Cited by 25 publications

References 22 publications

High spatial resolution inorganic scintillator detector for high‐energy X‐ray beam at small field irradiation

High spatial resolution inorganic scintillator detector for high‐energy X‐ray beam at small field irradiation

Advances on inorganic scintillator-based optic fiber dosimeters

High resolution small‐scale inorganic scintillator detector: HDR brachytherapy application

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