Dosimetric Parameters of Acute Hematologic Toxicity in Cervical Cancer Patients Treated With Concurrent Cisplatin and Pelvic Radiation Therapy: Turkish Oncology Group Gynecological Tumor Subgroup Study

Erpolat, P.; Alço, Gül; Igdem, Sefik; Aslay, N. Dagoglu I.; Demirci, Zühal; Güney, Ercihan; Kılıç, Mehtap; Etiz, E. Bayman D.; Mandel, Nil Molınas

doi:10.1016/j.ijrobp.2012.07.1167

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“…With the continuous improvement of radiotherapy, the incidence of HT has decreased significantly. Studies have shown that IMRT significantly reduces the dose and volume of pelvic radiation compared with 3D-CRT 22 . IMRT has been proved to considerably reduce the volume of pelvic bone marrow receiving high-dose radiation, such as V30Gy, V40Gy, and V50Gy, as well as the incidence of grade 2 or above acute HT 23 .…”

Section: Discussionmentioning

confidence: 99%

The effect of radiotherapy time and dose on acute hematologic toxicity during concurrent postoperative chemoradiotherapy for early high-risk cervical cancer

Yang¹,

Li²,

Zhang³

et al. 2023

J. Cancer

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Objective: This study aims to analyze the characteristics and factors that influence acute hematological toxicity (HT) during concurrent chemoradiotherapy (CCRT) for cervical cancer, as well as to provide reference data for clinical practice. Methods: Patients with FIGO IB1-IIA2 cervical cancer who underwent CCRT from May 2018 to August 2020 were included in this study retrospectively. All patients had received external beam radiation therapy and platinum-based concurrent chemotherapy. HT was assessed according to CTCAE 5.0. The pelvic bone marrow was redrawn on the original CT images and divided into four parts: the whole pelvic bone marrow (WP-BM), iliac bone marrow (IL-BM), lower pelvic bone marrow (LP-BM), and lumbosacral bone marrow (LS-BM). The radiation dose and volume of each part of the pelvic bone marrow were recalculated in a new plan created using the original planning parameters. The corresponding dose-volume histogram (DVH) was generated to obtain the bone marrow volumes receiving 10Gy, 20Gy, 30Gy, 40Gy, 45Gy, and 50Gy. Results: In 112 patients, the incidences of grade 2 or higher leukopenia, anemia, thrombocytopenia, and neutropenia were 49.1%, 2.7%, 1.8%, and 20.5%, respectively. Leukopenia was linked to LS-V20 (r = -0.310; P = 0.006) and radiotherapy treatment lengths (days) (r = -0.416; P = 0.013).

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Section: Discussionmentioning

confidence: 99%