2015
DOI: 10.1128/iai.00461-15
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Dot/Icm Effector Translocation by Legionella longbeachae Creates a Replicative Vacuole Similar to That of Legionella pneumophila despite Translocation of Distinct Effector Repertoires

Abstract: Legionella organisms are environmental bacteria and accidental human pathogens that can cause severe pneumonia, termed Legionnaires' disease. These bacteria replicate within a pathogen-derived vacuole termed the Legionella-containing vacuole (LCV). Our understanding of the development and dynamics of this vacuole is based on extensive analysis of Legionella pneumophila. Here, we have characterized the Legionella longbeachae replicative vacuole (longbeachae-LCV) and demonstrated that, despite important genomic … Show more

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Cited by 22 publications
(31 citation statements)
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“…Legionella longbeachae replicates within eukaryotic phagocytes using a Dot/Icm secretion system (39). Although the L. longbeachae Dot/Icm secretion system is highly similar to that of L. pneumophila , their effector repertoires are quite distinct and L. longbeachae does not encode a homolog of legC4 (48, 49).…”
Section: Resultsmentioning
confidence: 99%
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“…Legionella longbeachae replicates within eukaryotic phagocytes using a Dot/Icm secretion system (39). Although the L. longbeachae Dot/Icm secretion system is highly similar to that of L. pneumophila , their effector repertoires are quite distinct and L. longbeachae does not encode a homolog of legC4 (48, 49).…”
Section: Resultsmentioning
confidence: 99%
“…Similar to L. pneumophila, L. longbeachae replicates within an LCV by employing a Dot/Icm secretion system and a repertoire of translocated effector proteins (39). Despite high levels of homology between the Dot/Icm secretion systems of these two organisms, the effector repertoires are quite diverse and L. longbeachae does not encode a homolog of legC4 (48, 49).…”
Section: Discussionmentioning
confidence: 99%
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