Double-blind efficacy study of selenium sulfide in tinea versicolor

Sánchez, Jorge; Torres, Víctor

doi:10.1016/s0190-9622(84)70155-1

Cited by 36 publications

(7 citation statements)

References 6 publications

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“…Among the topical regimens, shampoos containing fungicidal concentrations of antifungal imidazoles, applied once daily for up to 4 weeks, were found to be adequately effective for the treatment of pityriasis versicolor (83). However, older studies also documented that nonimidazole topical agent formulations (zinc pyrithione shampoo, sulfur-salicylic acid shampoo, and selenium sulfide lotion) are sufficiently effective treatment options compared to placebo (21,104,276). More recently, pathophysiologically designed topical therapeutic approaches that target certain aspects of pityriasis versicolor pathogenesis are under clinical evaluation.…”

Section: Pityriasis Versicolormentioning

confidence: 99%

The Malassezia Genus in Skin and Systemic Diseases

et al. 2012

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SUMMARY In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur , M. pachydermatis , M. sympodialis , M. globosa , M. obtusa , M. restricta , and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis , M. japonica , M. yamatoensis , M. nana , M. caprae , M. equina , and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species and skin diseases. Hitherto, basic and clinical research has established etiological links between Malassezia yeasts, pityriasis versicolor, and sepsis of neonates and immunocompromised individuals. Their role in aggravating seborrheic dermatitis, dandruff, folliculitis, and onychomycosis, though often supported by histopathological evidence and favorable antifungal therapeutic outcomes, remains under investigation. A close association between skin and Malassezia IgE binding allergens in atopic eczema has been shown, while laboratory data support a role in psoriasis exacerbations. Finally, metabolomic research resulted in the proposal of a hypothesis on the contribution of Malassezia -synthesized aryl hydrocarbon receptor (AhR) ligands to basal cell carcinoma through UV radiation-induced carcinogenesis.

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Section: Pityriasis Versicolormentioning

confidence: 99%

The Malassezia Genus in Skin and Systemic Diseases

et al. 2012

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“…Available as a 2.5% lotion, cream or shampoo. It has been effective in the treatment of pityriasis versicolor 135,136 . Some patients may complain about its unpleasant odour 136 …”

Section: Treatmentmentioning

confidence: 99%

Pityriasis versicolor

Gupta

Bluhm

Summerbell

2002

Acad Dermatol Venereol

153

168

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“…194 Selenium sulfide, available as a shampoo, lotion and cream in 1-2.5% concentrations, is safe and effective in the treatment of tinea versicolor. 147,[195][196][197] Studies have shown that the success rate of selenium sulfide shampoo in the treatment of tinea versicolor is comparable to that of topical bifonazole and econazole. 198,199 Advantages of selenium sulfide include over-the-counter availability, low cost and convenient application.…”

Section: Non-specific Topical Antifungal Agentsmentioning

confidence: 99%

“…Disadvantages include irritation of the skin, unpleasant odour, staining of clothes and bedding, and a high relapse rate. 195,196 The efficacy of zinc pyrithione 1% shampoo versus its vehicle in the treatment of tinea versicolor has been shown in an open trial 200 as well as in a double-blind controlled trial. 201 In the latter, 20 patients with tinea versicolor were treated with either zinc pyrithione 1% shampoo or the shampoo base for 5 minutes per day for 2 weeks.…”

Section: Non-specific Topical Antifungal Agentsmentioning

confidence: 99%

Tinea versicolor: an updated review

Leung¹,

Barankin²,

Lam³

et al. 2022

DIC

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A search was conducted in July 2022 in PubMed Clinical Queries using the key terms "tinea versicolor" OR "pityriasis versicolor". The search strategy included all clinical trials (including open trials, non-randomized controlled trials and randomized controlled trials), observational studies and reviews (including narrative reviews and meta-analyses) published within the past 10 years. Only papers published in the English literature were included in this review. The information retrieved from the search was used in the compilation of this article. Review AetiopathogenesisTinea versicolor is caused by dimorphic lipophilic and lipid-dependent yeasts in the genus Malassezia (formerly known as Pityrosporum) species, notably Malassezia globosa (M. globose), M. furfur and M. sympodialis. [2][3][4][5][6][7][8][9][10][11][12] Other species that have been implicated include M. restricta, M. obtuse, M. slooffiae, M. pachydermatis and M. japonica. [13][14][15][16] These yeasts are normal commensals on the skin surface. 17,18 Skin colonization increases with age; 25% of children and almost 100% of adults are affected. 19 Tinea versicolor occurs when the saprophytic yeast or budding form of the organism converts to the pathogenic hyphal or mycelial form. The fungal infection is localized to the stratum corneum. Predisposing factors for the conversion include a hot and humid environment, hyperhidrosis, application of oily lotion or cream to the skin, wearing of masks, excessive lipid-containing sebaceous secretions, malnutrition, poor general health, use of oral contraceptives, pregnancy, diabetes mellitus, use of topical or systemic corticosteroids, Cushing disease, Helicobacter pylori infection, immunodeficiency and genetic predisposition. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] A recent study showed oxidative stress has no role in the pathogenesis of tinea versicolor. 29

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Double-blind efficacy study of selenium sulfide in tinea versicolor

Cited by 36 publications

References 6 publications

The Malassezia Genus in Skin and Systemic Diseases

The Malassezia Genus in Skin and Systemic Diseases

Pityriasis versicolor

Tinea versicolor: an updated review

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