Double-blind, placebo-controlled study comparing effects of zopiclone and temazepam on cognitive functioning of insomniacs

Stip, Émmanuel; Furlan, Monique; Lussier, Isabelle; Bourgouin, Pierre; Elie, Robert

doi:10.1002/(sici)1099-1077(199906)14:4<253::aid-hup97>3.0.co;2-i

Cited by 9 publications

References 31 publications

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Sedative‐Hypnotics

Vida¹,

Yevich

2003

Burger's Medicinal Chemistry and Drug Discovery

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This chapter focuses on sedative‐hypnotic drugs that are sued to alleviate the condition of sleep disturbances. One‐third of our life is spent in sleep; the lack, of which, can cause serious physical, social, and psychological problems. This chapter describes the features of an ideal hypnotic drug and provides a classification of sedative‐hypnotic drugs currently in use. These include the barbiturates, benzodiazepines, halogenated sedative‐hypnotics, heterocyclic sedative‐hypnotics, antihistamines, and other sedative‐hypnotics. Individual members of all of these classes of drugs are discussed in detail. The chapter also describes the physiology of sleep and the sleep cycle, including the nonrapid eye movement and rapid eye movement sleep. A list of neurotransmitters and nonhypnotic drugs that have a direct and indirect action on the sleep cycle are provided. The pharmacology including the evaluation of sedative‐hypnotics are also given. The chapter refers to the discovery of one of the most frequently prescribed hypnotic drugs, Zolpidem. The chapter also examines structure‐activity relationships, recent developments, things to come, and available websites.

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Sedative‐Hypnotics

Vida¹,

Yevich

2003

Burger's Medicinal Chemistry and Drug Discovery

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Comparative efficacy of newer hypnotic drugs for the short‐term management of insomnia: a systematic review and meta‐analysis

Dündar

Dodd

Strobl

et al. 2004

Human Psychopharmacology

156

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Twenty four eligible studies were identified with a total study population of 3,909 (17 studies comparing a Z-drug with a benzodiazepine and 7 comparing a Z-drug). Insufficient or inappropriately reported data meant that meta-analysis was possible only for a small number of outcomes. There are few clear, consistent differences between the drugs. Some evidence suggests that zaleplon gives shorter sleep latency but shorter duration of sleep than zolpidem, reflecting the pharmacological profiles of the drugs.

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