Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin® Forte) for treatment of male  infertility

Гамидов, С. И.; Овчинников, Р. И.; Popova, Alina

doi:10.18565/urology.2019.4.62-68

Cited by 3 publications

(2 citation statements)

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“…Carnitine penetrates into the mitochondrial matrix, and carnitine acetyltransferase converts ALC into LC and acetyl-CoA (41). Because LC and ALC are transformed into each other in the body, the LC and ALC contents were positively correlated (MDD: r = 0.273, P = 0.01, HC: r = 0.293, P = 0.005), many studies have officially confirmed that LC and ALC have a synergistic effect on the treatment of diseases (42,43), and ROC analysis showed that AUC of patients with MDD and HC was 0.891 when LC and ALC were considered together. LC and ALC may therefore be considered potential biomarkers of depression simultaneously.…”

Section: Discussionmentioning

confidence: 99%

L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder

et al. 2021

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The lack of biomarkers greatly limits the diagnosis and treatment of major depressive disorder (MDD). Endogenous L-carnitine (LC) and its derivative acetyl-L-carnitine (ALC) play antidepressant roles by improving brain energy metabolism, regulating neurotransmitters and neural plasticity. The levels of ALC in people and rodents with depression are significantly reduced. It is necessary to determine whether serum LC and ALC might be used as novel biomarkers for the diagnosis of MDD. Here, ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to determine the concentration of LC and ALC in the serum of healthy controls and patients with MDD; among the latter, in patients who were responsive (effective group) and non-responsive (ineffective group) after 2 weeks of treatment. The diagnostic value of serum LC and ALC for MDD was assessed. Compared with healthy controls, the serum LC and ALC concentrations in patients with MDD were significantly decreased (P < 0.001). Pearson correlation analysis shows that the HDRS-24 score was negatively associated with serum ALC (r = −0.325, P = 0.007). Receiver operating characteristic (ROC) analysis revealed an area under the curve (AUC) of 0.801 with 83.1% sensitivity and 66.3% specificity for LC, and an AUC of 0.898 with 88.8% sensitivity and 76.4% specificity for ALC, differentiating patients with MDD from healthy controls. Furthermore, the concentration of LC and ALC in patients with depression was significantly increased in the effective treatment group, and no significant change was observed in the ineffective treatment group. These results suggest that serum LC and ALC may be novel biomarkers for the diagnosis of MDD.

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Section: Discussionmentioning

confidence: 99%

L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder

et al. 2021

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“…ALC exhibits a variety of physiological activities, including nutritional effects, neuroprotective effects, analgesic effects of the peripheral nervous system, antioxidant effects, and plays important roles in the functioning of male reproductive system. Commercially, ALC‐based drugs are mainly used to improve male fertility, treat Alzheimer’s disease, hepatic encephalopathy, depression, and diabetic peripheral neuropathy (Anikin, Makhova, & Shikh, 2019; Di Stefano, Di Lionardo, Galosi, Truini, & Cruccu, 2019; Gamidov, Ovchinnikov, & Popova, 2019; Jeong et al, 2017; Ponomareva, 2017; Rolim, da Silva, Flumignan, Abreu, & Dib, 2019).…”

Section: Introductionmentioning

confidence: 99%

A UPLC–MS/MS method for determination of endogenous l‐carnitine and acetyl‐l‐carnitine in serum of patients with depression

Nie

Liang

Shan

et al. 2020

Biomedical Chromatography

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A simple, rapid, and selective ultra‐performance liquid chromatography–tandem mass spectrometry method for determination of l‐carnitine (LC) and acetyl‐l‐carnitine (ALC) in human serum was developed. Acetyl‐l‐carnitine‐d3 (ALC‐d3) was selected as internal standard (IS). After protein precipitation with acetonitrile–water (1 mL, 2:1, v/v), the analytes and IS were separated on a 2.5‐μm XSelect HSS T3 C18 column by gradient elution with methanol–water (containing 0.01% ammonia water) as the mobile phase at a flow rate of 0.2 mL/min. Analytes were detected with multiple reaction monitoring using a positive scan mode with electrospray ionization. Good linearity (R2 > 0.999) was observed in the concentration range for LC and ALC. The inter‐ and intra‐day values of relative error were −10.4% to 10.0% with CVs less than 9.84%. The average recoveries of the two analytes were 91.29%–98.23%. Blood samples containing LC and ALC were stable under various storage conditions. Normal, haemolytic, and hyperlipidaemic serum had no significant effect on the quantification of LC and ALC. This method was successfully applied to study the concentrations of endogenous LC and ALC in the serum of patients with first‐episode depression.

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RETRACTED ARTICLE: Ellagic Acid Improves Testicular Dysfunction via Autophagy in a Tamoxifen-Injured Rat Model

Olfati

Khamisabadi

2020

J Evol Biochem Phys

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Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin® Forte) for treatment of male infertility

Cited by 3 publications

References 0 publications

L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder

L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder

A UPLC–MS/MS method for determination of endogenous l‐carnitine and acetyl‐l‐carnitine in serum of patients with depression

RETRACTED ARTICLE: Ellagic Acid Improves Testicular Dysfunction via Autophagy in a Tamoxifen-Injured Rat Model

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