Double-blind randomized placebo-controlled study of bixa orellana in patients with lower urinary tract symptoms associated to benign prostatic hyperplasia

Abstract

Patients with BPH that present moderate LUTS did not show any benefit receiving BO when compared to placebo.

Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia: systematic review of randomized controlled trials

“…Twenty studies (64.5%) were rated as low-quality randomized controlled trials (RCTs) (Jadad score f2), and the remaining 11 (35.5%) were rated as moderate-to-high (Jadad score o3). Table 2 presents the characteristics of the 11 moderate to high quality studies [26][27][28][29][30][31][32][33][34][35][36] that were selected for detailed analysis. All 11 of the studies were reported as randomized trials; only one (Study 6) 33 did not describe the method of randomisation.…”

“…Table 2 presents the characteristics of the 11 moderate to high quality studies [26][27][28][29][30][31][32][33][34][35][36] that were selected for detailed analysis. All 11 of the studies were reported as randomized trials; only one (Study 6) 33 did not describe the method of randomisation. Five trials fulfilled the criteria of a double-blind study design and provided an appropriate description of the double-blind method (Studies 3, 4, 5, 6 and 11).…”

“…Five trials fulfilled the criteria of a double-blind study design and provided an appropriate description of the double-blind method (Studies 3, 4, 5, 6 and 11). 27,[31][32][33]35 Only four studies described the dropouts and listed the reasons (Studies 4, 5, 6 and 9). 27,28,32,33 Assessment by the Cochrane's risks of bias assessment Figures 2 and 3 display the proportion and summary of the high, low and unclear risk of bias of 11 studies with Jadad scores o3.…”

Safety and Efficacy of Bixa orellana (Achiote, Annatto) Leaf Extracts

“…Animal studies have shown that doses of extracts as high as over 3000 mg equivalent human dose produce pharmacological effects. Approximately 30% of leaf material is extractable, suggesting that the daily dose used in this study was equivalent to about 250 mg, a dose that may have been too low to product an effect (Zegarra et al ., ). Alternatively, the endpoints measured were symptoms associated with benign prostatic hypertrophy, and the product simply did not have an effect on these symptoms.…”

Limited clinical evidence to support the integration of Caribbean herbs into conventional medicine

“…While there is no clinical support for this folkloric use, a single clinical study found C. citrates reduced oral thrush in patients with HIV/AIDS, 25 which suggests the herb may have anti-fungal properties. 34 In Cuba, Annona muricata, Annona reticulata, Citrus aurantifolia (bitter orange) and B. pilosa are administered together as a poly-herbal preparation for the treatment of hypertension. Limited clinical evidence has shown that it may reduce fasting and postprandial glucose, 26 as well as possess immunomodulatory properties.…”