Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of sulphasalazine in preventing acute gastrointestinal complications due to radiotherapy

Research and Development of Radioprotective Agents: A Mini-Review

“…For examples, glutamine, a non-essential amino acid was widely studied for its potential protective effect on mucositis, dermatitis and oespahagitis [114][115][116][117] ; pentoxifyline, a methyl xanthine derivative, decreased the risk of radiation toxicity in lung [118] ; benzydamine could prevent and treat oral mucositis [119] ; and sulfasalazine was evaluated for its effects on radiotherapy-induced enteritis [120] . To date, there are still a limited number of chemical RAs clinically used to minimize the severity and duration of toxicities associated with radiotherapy.…”

The Efficacy of the Combination Therapy with Oral and Topical Mesalazine for Patients with the First Episode of Radiation Proctitis

“…Some authors have investigated the effects of sulfasalazine and its active component, 5-aminosalicylic acid (5-ASA), in the prevention of acute radiation toxicity. The results from previous studies of 5-ASA and its precursors have been controversial [12][13][14][15][16][17][18][19]. The combination of oral and topical 5-ASA may produce a better response in the management of mild to moderate distal colitis than administration of the oral or topical formulation alone [20].…”

Obscure gastrointestinal bleeding: a complication of radiation enteritis diagnosed by wireless capsule endoscopy

“…Our efforts should therefore focus on prevention, either with medication that protects against radiation or anti-inflammatory treatment (16). Also helpful would be the use of absorbable mesh slings which separate the intestine from the field of radiation (17).…”

“…Nuestros esfuerzos deberán centrarse, por lo tanto, en la prevención ya sea con radioprotectores o antiinflamatorios (16), o usando mallas reabsorbibles que alejen el intestino del campo de la radiación (17). Nuestra paciente rechazó el tratamiento quirúrgico una vez se llegó al diagnóstico.…”