Double crosslinking decellularized bovine pericardium of dialdehyde chondroitin sulfate and zwitterionic copolymer for bioprosthetic heart valves with enhanced antithrombogenic, anti-inflammatory and anti-calcification properties

Shi, Shubin; Hu, Mengyue; Peng, Xu; Cheng, Can; Feng, Shaoxiong; Pu, Xinyun; Yu, Xixun

doi:10.1039/d4tb00074a

Cited by 3 publications

(1 citation statement)

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“…Glutaraldehyde (GA) cross-linked collagen improved collagen's thermal stability and anti-enzyme activity. Nonetheless, GA posed potential risks of cytotoxicity and calcification [17,18]. The process of cross-linking involving 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) bolstered the mechanical resilience of collagen.…”

Section: Introductionmentioning

confidence: 99%

Engineering a durable BDDE cross-linked collagen filler for skin rejuvenation

Wang,

Yan,

Zhang

et al. 2024

Biomed. Mater.

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Skin aging, characterized by reduced regeneration, chronic inflammation, and heightened skin cancer risk, poses a significant challenge. Collagen fillers have emerged as a potential solution for skin rejuvenation by stimulating collagen regeneration. However, their clinical efficacy is limited by inherent instability and vulnerability to in vivo degradation by collagenase. Chemical cross-linking presents a promising approach to enhance stability, but it carries risks such as cytotoxicity, calcification, and discoloration. Here, we introduce a highly durable 1,4-butanediol diglycidyl ether (BDDE) cross-linked collagen filler for skin rejuvenation. BDDE effectively cross-links collagen, resulting in fillers with exceptional mechanical strength and injectability. These fillers demonstrate favorable stability and durability, promoting proliferation, adhesion, and spreading of human foreskin fibroblast-1 cells in vitro. In vivo studies confirm enhanced collagen regeneration without inducing calcification. BDDE cross-linked collagen fillers offer promising prospects for medical cosmetology and tissue regeneration.

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Section: Introductionmentioning

confidence: 99%