2024
DOI: 10.21608/jrme.2024.264068.1007
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Double Ionophore Activation (DIA) technique in cases of severe male factor: Case Series

Dalal Guiziry,
Nehal Adel,
Mohammed Faris
et al.

Abstract: Background: Sperm binding or injection into human oocytes induces calcium oscillations resulting in oocyte activation, fertilization, and subsequent embryonic development. In severe male factor, sperm may fail to activate oocytes with subsequent ICSI failure. Artificial oocyte activation with calcium ionophore can induce calcium influx with improved oocyte activation and development.Objective: The current case series evaluated a unique technique of double ionophore activation (DIA) in severe male factor withou… Show more

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