Double or hybrid diabetes: A systematic review on disease prevalence, characteristics and risk factors

Khawandanah, Jomana

doi:10.1038/s41387-019-0101-1

Cited by 91 publications

(63 citation statements)

References 117 publications

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“…DM is a group of chronic metabolic diseases characterized by persistently increased blood glucose levels [ 64 ] resulting from defects in insulin secretion, loss of insulin responsiveness, or both [ 65 ]. Commonly DM is classified into two main types, type 1 (T1DM) and type 2 (T2DM).…”

Section: Diabetes Mellitus—is It An Epidemic?mentioning

confidence: 99%

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

Puchałowicz

Rać

2020

Cells

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CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes cells sensitive to metabolic abnormalities associated with metabolic syndrome and diabetes mellitus (DM), such as monocytes and macrophages, epithelial cells, adipocytes, hepatocytes, skeletal and cardiac myocytes, pancreatic β-cells, kidney glomeruli and tubules cells, pericytes and pigment epithelium cells of the retina, and Schwann cells. These features make CD36 an important component of the pathogenesis of DM and its complications, but also a promising target in the treatment of these disorders. The detrimental effects of CD36 signaling are mediated by the uptake of fatty acids and modified lipoproteins, deposition of lipids and their lipotoxicity, alterations in insulin response and the utilization of energy substrates, oxidative stress, inflammation, apoptosis, and fibrosis leading to the progressive, often irreversible organ dysfunction. This review summarizes the extensive knowledge of the contribution of CD36 to DM and its complications, including nephropathy, retinopathy, peripheral neuropathy, and cardiomyopathy.

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Section: Diabetes Mellitus—is It An Epidemic?mentioning

confidence: 99%

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

Puchałowicz

Rać

2020

Cells

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“…Insulin resistance is common to both T1D and T2D, although its pathophysiology seems to be different in youth with T1D, as compared to those with T2D [ 36 ]. The simultaneous presence of insulin resistance and T1D has been defined as “hybrid or double diabetes” and patients with T1D and insulin resistance own a more elevated CV risk among patients with T1D [ 37 ]. The control of other abnormalities associated with diabetes is of paramount importance.…”

Section: CV Risk Factors In Children and Adolescents With Diabetesmentioning

confidence: 99%

The Impact of Diabetes Mellitus on Cardiovascular Risk Onset in Children and Adolescents

Pastore

Bolla

Montefusco

et al. 2020

IJMS

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The prevalence of diabetes mellitus is rising among children and adolescents worldwide. Cardiovascular diseases are the main cause of morbidity and mortality in diabetic patients. We review the impact of diabetes on establishing, during childhood and adolescence, the premises for cardiovascular diseases later in life. Interestingly, it seems that hyperglycemia is not the only factor that establishes an increased cardiovascular risk in adolescence. Other factors have been recognized to play a role in triggering the onset of latent cardiovascular diseases in the pediatric population. Among these cardiovascular risk factors, some are modifiable: glucose variability, hypoglycemia, obesity, insulin resistance, waist circumference, hypertension, dyslipidemia, smoking alcohol, microalbuminuria and smoking. Others are unmodifiable, such as diabetes duration and family history. Among the etiological factors, subclinical endothelial dysfunction represents one of the earliest key players of atherosclerosis and it can be detected during early ages in patients with diabetes. A better assessment of cardiovascular risk in pediatric population still represents a challenge for clinicians, and thus further efforts are required to properly identify and treat pediatric patients who may suffer from cardiovascular disease later in early adulthood.

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“…Since precise definition and diagnosis of type 1 and type 2 diabetes has become more difficult and very challenging, a new category of diabetes termed double or hybrid diabetes has been introduced. Double diabetes possesses symptoms of both type 1 and type 2 diabetes including obesity, insulin resistance, type of latent autoimmune diabetes in youth (LADY) autoantibodies (namely GAD56, IA2), and insulin antibodies [ 12 ].…”

Section: Diabetes—sweet and Silent Killer But Not Unbeatablementioning

confidence: 99%

The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level

Jovanović

Mihailović

Uskoković

et al. 2021

JoF

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Diabetes mellitus is a life-threatening multifactorial metabolic disorder characterized by high level of glucose in the blood. Diabetes and its chronic complications have a significant impact on human life, health systems, and countries’ economies. Currently, there are many commercial hypoglycemic drugs that are effective in controlling hyperglycemia but with several serious side-effects and without a sufficient capacity to significantly alter the course of diabetic complications. Over many centuries mushrooms and their bioactive compounds have been used in the treatment of diabetes mellitus, especially polysaccharides and terpenoids derived from various mushroom species. This review summarizes the effects of these main mushroom secondary metabolites on diabetes and underlying molecular mechanisms responsible for lowering blood glucose. In vivo and in vitro data revealed that treatment with mushroom polysaccharides displayed an anti-hyperglycemic effect by inhibiting glucose absorption efficacy, enhancing pancreatic β-cell mass, and increasing insulin-signaling pathways. Mushroom terpenoids act as inhibitors of α-glucosidase and as insulin sensitizers through activation of PPARγ in order to reduce hyperglycemia in animal models of diabetes. In conclusion, mushroom polysaccharides and terpenoids can effectively ameliorate hyperglycemia by various mechanisms and can be used as supportive candidates for prevention and control of diabetes in the future.

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Double or hybrid diabetes: A systematic review on disease prevalence, characteristics and risk factors

Cited by 91 publications

References 117 publications

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

The Impact of Diabetes Mellitus on Cardiovascular Risk Onset in Children and Adolescents

The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level

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