Double-Pass Retina Point Imaging for the Evaluation of Optical Light Scatter, Retinal Image Quality, and Staging of Keratoconus

Leonard, Anthony; Gardner, Scott D.; Rocha, Karolinne Maia; Zeldin, Evan R; Tremblay, David; Waring, George O.

doi:10.3928/1081597x-20160728-02

Cited by 20 publications

(20 citation statements)

References 32 publications

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“…ese results were consistent with those given by Ye et al [12], but they did not evaluate the OSI value. Leonard et al [13] compared the OSI values between the keratoconus eyes and normal eyes and found statistically significant increments of OSI scores in the AK1 and AK2 group, which was also consistent with our results. However, our results further showed the OSI had no significant difference between the FFK and normal group.…”

Section: Discussionsupporting

confidence: 93%

“…Ye et al [12] found that the modulation transfer function cutoff (MTF cutoff), Strehl ratio (SR), OQAS values at contrasts of 100% (OV-100), OQAS values at contrasts of 20% (OV- 20), and OQAS values at contrasts of 9% (OV-9) had significant differences between the normal and forme fruste keratoconus (FFK) patients. Leonard et al [13] reported that the OSI was increased in keratoconic eyes and could be considered as a clinically significant parameter to stage keratoconus by directly evaluating visual quality. However, to the best of our knowledge, comparisons of all the parameters among FFK, mild keratoconus, moderate keratoconus patients, and normal have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Visual Quality in Eyes with Forme Fruste Keratoconus and Mild and Moderate Keratoconus Based on Optical Quality Analysis System II Parameters

Ren

Fan

et al. 2020

Journal of Ophthalmology

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Purpose. The study aimed to evaluate the visual quality of forme fruste keratoconus (FFK) and mild and moderate keratoconus by using an optical quality analysis system II (OQAS-II) and to explore the correlation between optical quality parameters and the disease progression. Methods. Twenty-one normal eyes, twenty-one FFK eyes, twenty-one mild keratoconus eyes, and twenty-one moderate keratoconus eyes were included in this prospective study. The optical quality parameters, such as object scatter index (OSI), modulation transfer function cutoff (MTF cutoff), strehl ratio (SR), and OQAS-II values at contrasts of 100% (OV-100), 20% (OV-20), and 9% (OV-9), were measured by OQAS-II. The repeatability of these parameters was analyzed by intraclass correlation coefficient (ICC), repeatability coefficient (RC), and coefficient of variation (CVw). Correlations between optical quality parameters and mean central keratometry readings (Kmean) were evaluated. The sensitivity and specificity of the parameters were analyzed using the receiver operating characteristic (ROC). Results. All the optical quality parameters among four groups showed good repeatability (all ICC≥0.75). The MTF cutoff, SR, OV-100, OV-20, OV-9 in FFK, mild and moderate keratoconus eyes were significantly lower than those in the normal group (all P<0.05). The ROC analyses of the MTF cutoff, SR, OV-100, OV-20, and OV-9 showed significant area under the curve (AUC) in discriminating FFK form normal, mild keratoconus from FFK, and moderate keratoconus from mild keratoconus (all P<0.05). The OSI in mild and moderate keratoconus eyes were significantly higher than that in FFK and normal group (all P<0.05), while the OSI showed no significant difference between the FFK group and normal group (P>0.05). The ROC analyses of the OSI showed significant AUC in discriminating mild keratoconus from FFK and moderate keratoconus from mild keratoconus (all P<0.05). In addition, the MTF cutoff was closely correlated to Kmean in keratoconus eyes (r = −0.710, P<0.001). Conclusion. The repeatability of OQAS-II is good in measuring visual quality of normal as well as FFK, mild, and moderate keratoconus. The visual quality of the FFK, mild, and moderate keratoconus is worse than that in normal eyes. The OQAS-II has the potential value in screening FFK from normal eyes and might be a useful tool for evaluating the progression of keratoconus.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Assessment of Visual Quality in Eyes with Forme Fruste Keratoconus and Mild and Moderate Keratoconus Based on Optical Quality Analysis System II Parameters

Ren

Fan

et al. 2020

Journal of Ophthalmology

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“…Forward light scatter detects the light that does not come into focus on the retina because of aberrations within the optical system, resulting in halos, glares, and difficulty during driving under scotopic conditions (8) . Double-pass retinal imaging (DPRI) can be used to analyze the point-spread function (PSF) directly from the retinal image; it is a validated and reproducible technology designed to evaluate forward light scatter through the optical system (9)(10)(11) . The method enables mathematical reconstruction of the entire optical system allowing the clinician to "see" images as they are cast onto the patient's retina and perceived by the patient (11) .…”

Section: Introductionmentioning

confidence: 99%

Objective evaluation of vision quality in pseudophakic patients with posterior capsular opacification using double-pass retinal imaging

McMillin¹,

Rocha²,

Barnwell³

et al. 2019

Arquivos Brasileiros De Oftalmologia

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The purpose of this study was to objectively assess the optical vision quality of patients before and after Nd:YAG capsulotomy for posterior capsular opacification using a double-pass retinal imaging system. Methods: We retrospectively analyzed the data from 26 pseudophakic eyes with posterior capsular opacification that underwent Nd:YAG capsulotomy. The objective scatter indices, modulation transfer function cutoff frequencies, Strehl ratios, and logMAR corrected distance visual acuities were assessed before and after YAG capsulotomy with a double-pass retinal imaging system (OQAS II, Visiometrics, Spain). We also analyzed data from a subgroup of 10 patients with pre-YAG corrected distance visual acuity of 0.10 logMAR (20/25) or better. Results: Vision quality indices improved in all 26 eyes, resulting in a statistically significant improvement in the corrected distance visual acuity (p=0.007), objective scatter index (p=0.001), modulation transfer function cutoff frequency (p=0.001), and Strehl ratio (p=0.020). The overall mean improvements included 0.12 ± 0.04 logMAR for corrected distance visual acuity, 2.84 ± 0.76 for objective scatter index, 12.29 ± 2.77 for modulation transfer function cutoff frequency, and 0.06 ± 0.03 for Strehl ratio. Our sub-analysis of 10 eyes with 0.10 logMAR (20/25) corrected distance visual acuity or better also showed a statistically significant improvement in the mean objective scatter index (0.76 ± 16; p=0.001), resulting in approximately 35% decrease in intraocular light scatter. Conclusions: The objective vision quality measurements as assessed by the double-pass retinal imaging system showed a significant improvement after YAG capsulotomy. This suggests that the objective scatter index improves after YAG capsulotomy, even in eyes with pre-YAG 0.10 logMAR (Snellen 20/25) corrected distance visual acuity or better.

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“…; Leonard et al. ). Further studies will analyse a larger number of patients with different patterns of scatter, especially posterior subcapsular and cortical cataracts, as well as in different corneal pathologies that cause scattering and age‐matched controls.…”

Section: Discussionmentioning

confidence: 98%

“…An increase in the OSI has been observed in eyes with keratoconus (Leonard et al. ), and significant correlations have been found between the OSI and the logMAR in patients after corneal transplantation (Kamiya et al. ).…”

Section: Introductionmentioning

confidence: 98%

Quantification of forward scattering based on the analysis of double‐pass images in the frequency domain

Martínez‐roda

García-Guerra

Díaz-Doutón

et al. 2019

Acta Ophthalmologica

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PurposeTo assess forward intraocular scattering by means of a new parameter (Frequency Scatter Index, FSI3) based on the analysing double‐pass retinal images in the frequency domain, which minimizes the impact of aberrations on the results.MethodsA prospective observational study was carried out in the Department of Ophthalmology, Hospital Universitari Mútua de Terrassa (Spain) on a group of 19 patients diagnosed with nuclear cataracts of various LOCSIII grades and a control group (CG) with nine healthy eyes. We recorded double‐pass retinal images with a custom set‐up based on a high‐sensitivity digital camera. The FSI3 was then computed using spatial frequencies below three cycles per degree. A preliminary validation of the FSI3 was performed on an artificial eye and two eyes of volunteers with and without commercial diffusers, and under defocus.ResultsThe FSI3 was hardly affected by defocus values up to 2.50 D. The mean (and standard deviation) FSI3 values were as follows: for the CG, 1.19 (0.21); and for LOCSIII grades nuclear opacity 1, 2 and 3, 1.30 (0.12), 1.62 (0.21) and 1.85 (0.21), respectively. Eyes with cataracts showed FSI3 values significantly different than healthy eyes (p = 0.001). A good correlation (ρ = 0.861, p < 0.001) was found between the FSI3 and objective scatter index provided by a commercial instrument.ConclusionSince aberrations have little impact on the FSI3, the light scatter assessment becomes less dependent on the patient's refractive error compensation and the presence of higher‐order aberrations. The FSI3 can further the clinical and scientific understanding of forward intraocular scattering.

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Double-Pass Retina Point Imaging for the Evaluation of Optical Light Scatter, Retinal Image Quality, and Staging of Keratoconus

Cited by 20 publications

References 32 publications

Assessment of Visual Quality in Eyes with Forme Fruste Keratoconus and Mild and Moderate Keratoconus Based on Optical Quality Analysis System II Parameters

Assessment of Visual Quality in Eyes with Forme Fruste Keratoconus and Mild and Moderate Keratoconus Based on Optical Quality Analysis System II Parameters

Objective evaluation of vision quality in pseudophakic patients with posterior capsular opacification using double-pass retinal imaging

Quantification of forward scattering based on the analysis of double‐pass images in the frequency domain

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