Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties

Idowu, Thomas Oyebode; Ogundaini, A. O.; Salau, A.O.; Obuotor, Efere Martins; Bezabih, Merhatibeb; Abegaz, Berhanu M.

doi:10.1016/j.phytochem.2010.08.018

Cited by 76 publications

(64 citation statements)

References 36 publications

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“…In addition, it has been reported that procyanidin B2 showed moderate activity against B. cereus with MIC value of 39.1 g mL -1 although the activity against other panthogenic bacteria was quite limited [70]. Such limited antibacterial activity has also been observed for procyanidin A2 against B. subtilis [71]. Compared with dimmers, the =avans trimmers seem to have a little higher antibacterial activity, and the oligomeric =avanols generally showed higher activity than the monomeric ones [71,72].…”

Section: Flavanolsmentioning

confidence: 88%

“…Such limited antibacterial activity has also been observed for procyanidin A2 against B. subtilis [71]. Compared with dimmers, the =avans trimmers seem to have a little higher antibacterial activity, and the oligomeric =avanols generally showed higher activity than the monomeric ones [71,72]. The antibacterial activlity of hydrocarbonyl substituted flavanols has not been fully studied, but the annular acylations on the A rings of catechin and procyanidin B2 have been reported to decrease their activity against S. aureus [73].…”

Section: Flavanolsmentioning

confidence: 99%

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Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Fei¹,

Yang²,

Tang³

et al. 2014

CMC

600

369

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Flavonoids are well known as antibacterial agents against a wide range of pathogenic microorganism. With increasing prevalence of untreatable infections induced by antibiotic resistance bacteria, flavonoids have attracted much interest because of the potential to be substitutes for antibiotics. In this review, the structure-relationship of flavonoids as antibacterial agents is summarized, and the recent advancements on the antibacterial mechanisms of flavonoids are also discussed. It is concluded that hydroxyls at special sites on the aromatic rings of flavonoids improve the activity. However, the methylation of the active hydroxyl groups generally decreases the activity. Besides, the lipopholicity of the ring A is vital for the activity of chalcones. The hydrophobic substituents such as prenyl groups, alkylamino chains, alkyl chains, and nitrogen or oxygen containing heterocyclic moieties usually enhance the activity for all the flavonoids. The proposed antibacterial mechanisms of flavonoids are as follows: inhibition of nucleic acid synthesis, inhibition of cytoplasmic membrane function, inhibition of energy metabolism, inhibition of the attachment and biofilm formation, inhibition of the porin on the cell membrane, alteration of the membrane permeability, and attenuation of the pathogenicity.

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Section: Flavanolsmentioning

confidence: 88%

Section: Flavanolsmentioning

confidence: 99%

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Fei¹,

Yang²,

Tang³

et al. 2014

CMC

600

369

View full text Add to dashboard Cite

show abstract

“…There are many reports in the literature regarding the biological activity of Ixora species [13][14][15][16][17][18][19][20][21][22][23] . The present work has shown that Ixora species was a potentially good source of antimicrobial agent and that further investigation is worthwhile to isolate and evaluate biologically active compounds from the crude extract.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological screening of methanolic extract of Ixora species

Latha

Demirtaş

Jain

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…15 cinnamtannin B-1 (10), 16 and protocatechuic acid methyl ester (11) 17 by comparison of their spectroscopic data with previously reported values.…”

Section: Resultsmentioning

confidence: 75%

Phytochemical Constituents from the Rhizomes ofOsmunda japonicaThunb and Their Anti-oxidant Activity

et al. 2017

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− Eleven compounds (1-11) were isolated from the rhizomes of Osmunda japonica, and their structures were elucidated based on 1 H, 13C-NMR and LC-IT-TOF MS data. Of these compounds, all compounds (1 -11) have been previously reported, although five (6 -9, 11) have not previously been isolated from this plant. The antioxidant activities of isolated compounds (1 -11) were measured by DPPH and ABTS assays, and compound 10 showed the high antioxidant activity.

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Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties

Cited by 76 publications

References 36 publications

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Pharmacological screening of methanolic extract of Ixora species

Phytochemical Constituents from the Rhizomes ofOsmunda japonicaThunb and Their Anti-oxidant Activity

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