Doubting the TCR Coreceptor Function of CD8αα

Cheroutre, Hilde; Lambolez, Florence

doi:10.1016/j.immuni.2008.01.005

Cited by 171 publications

(189 citation statements)

References 103 publications

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“…A less common CD8aa homodimer can be found on subsets of intraepithelial lymphocytes, both ab + and gd + T cells, mast cells, macrophages, NK cells and subsets of dendritic cells (38). In our study, the transcript levels of CD8a and CD8b were higher in the ILT compared with the other tissues examined.…”

Section: Discussionsupporting

confidence: 40%

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

Bergva

Austbø

König

et al. 2014

The Journal of Immunology

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Previously, our group has shown that the interbranchial lymphoid tissue (ILT) is a distinct structure largely consisting of T cells embedded in a meshwork of epithelial cells, with no direct resemblance to previously described lymphoid tissues. In this study, we aim to focus on the T cell population and the possibility of the ILT being a thymus analog. By characterizing structural responsiveness to Ag challenge, the presence of recombination activating genes, and different T cell–related transcripts, we attempt to further approach the immunological function of the ILT in salmonid gills. In addition to eight healthy individuals, a group of eight infectious salmon anemia virus–challenged fish were included to observe T cell responses related to infection. The results showed reduced size of ILT in the infected group, no expression of RAG-1 and -2, and a high degree of T cell diversity within the ILT. Taking into account that the ILT can be regarded as a strategically located T cell reservoir and possibly an evolutionary forerunner of mammalian MALTs right at the border to the external environment, the alteration in transcription observed may likely represent a shift in the T cell population to optimize local gill defense mechanisms.

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Section: Discussionsupporting

confidence: 40%

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

Bergva

Austbø

König

et al. 2014

The Journal of Immunology

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“…CD8aa type T cells represent a minor population in most lymphoid tissues but are one of the major populations in the mucosal tissues, where they are regarded as "innate type" T cells. Of note, the CD8aa homodimer does not function well as a TCR coreceptor, because it does not efficiently bind to MHC class I molecules (21). Although regenerated CD8 T cells in the previous studies all seemed to be of the innate type, in this study we describe a novel yet simple method to generate CD8ab T cells and show that they are active against leukemia.…”

Section: Introductionmentioning

confidence: 86%

Regeneration of CD8αβ T Cells from T-cell–Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity

et al. 2016

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Although adoptive transfer of cytotoxic T lymphocytes (CTL) offer a promising cancer therapeutic direction, the generation of antigen-specific CTL from patients has faced difficulty in efficient expansion in ex vivo culture. To resolve this issue, several groups have proposed that induced pluripotent stem cell technology be applied for the expansion of antigen-specific CTL, which retain expression of the same T-cell receptor as original CTL. However, in these previous studies, the regenerated CTL are mostly of the CD8aa þ innate type and have less antigen-specific cytotoxic activity than primary CTL. Here we report that, by stimulating purified iPSC-derived CD4/CD8 double-positive cells with anti-CD3 antibody, T cells expressing CD8ab were generated and exhibited improved antigen-specific cytotoxicity compared with CD8aa þ CTL. Failure of CD8ab T-cell production using the previous method was found to be due to killing of doublepositive cells by the double-negative cells in the mixed cultures. We found that WT1 tumor antigen-specific CTL regenerated by this method prolonged the survival of mice bearing WT1-expressing leukemic cells. Implementation of our methods may offer a useful clinical tool. Cancer Res; 76(23); 6839-50. Ó2016 AACR.

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“…However, they are consistent with murine data that suggest CD8␣␣ can be co-expressed on conventionally selected CD4, CD8␣␤ and DN T cells. 16,28,29,36,37 Culture experiments here used CD8 enriched PBMCs and so we are unable to comment on the possibility of induction of CD8␣␣ on CD4 and DN T cells in humans under similar experimental conditions. Given the existing mouse data, it will be important to look for these among gutderived lymphocytes in man.…”

mentioning

confidence: 99%

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells

Walker

Kang

Smith

et al. 2012

Blood

229

302

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Human mucosal associated invariant T (MAIT)CD8 IntroductionHuman mucosal associated invariant T cells (MAIT) are defined by an invariant usage of the T-cell receptor chain V␣ 7.2, restriction by the major histocompatibility complex (MHC)-related protein MR1, and most recently have been shown to exhibit high expression of the C-type lectin CD161 (CD161 ϩϩ ), and IL18R. 1 Human MAIT cells have been described to be CD8␣␤, CD8␣␣, or doublenegative (DN) although a differential role for these different subsets has not been explored. Independently, we have described a human tissue-homing CD161 ϩϩ CD8 ϩ T-cell subset to be Tc17 cells, enriched at inflammatory sites including liver and joints. 2 Type-17 function has been recently confirmed in the MAIT cell population. 3 CD161 ϩϩ CD8 ϩ and MAIT-cells share key differentiation factors with Th17 cells, including cytokine expression (IL-17A and IL22), transcription factors (ROR␥t and RUNX2), chemokine receptors (CCR6 and CCR2), and cytokine receptors (IL23R and IL18R). There is growing recognition that these data describe the same phenomenon in parallel or overlapping populations, although this has not been fully defined to date, and the relationship between the 2 subsets remains unclear. Given the recent emergence of these cell types in diverse diseases, including multiple sclerosis, 4 this remains a significant unanswered question.CD161 was first identified as a potential lineage identifier for human Th17 cells when it was found to be a highly up-regulated gene on microarray comparison of gene expression between Th1, Th2, and Th17 clones, and circulating Th17 cells were contained within the CCR6 ϩ CD161 ϩ CD4 ϩ population. 5 Cord blood CD161 ϩ CD4 ϩ CD8 Ϫ , CD8 ϩ CD4 Ϫ and CD4 Ϫ CD8 Ϫ TCR␣␤ ϩ , and TCR␥␦ ϩ cells already express IL-23R and ROR␥t mRNA, and produce IL-17, unlike their CD161 counterparts. The transcription factor ROR␥t has been defined as the driver for the hallmark features of these cells, as CD161, IL-23R, and IL-17 expression could be directly induced by RORC2 transduction of CD161-cord cells. 6 In humans, CD161/NKR-P1A encoded by the KLRB1 gene, is expressed by a wide variety of human immune cells; natural killer (NK) cells, NK T cells, CD4 ϩ T cells, CD8 ϩ T cells, and ␥␦ T cells. Lectin-like transcript-1 (LLT1) 7,8 and PILAR 9 have been identified as ligands for CD161, although the role of such ligation on CD161 ϩϩ CD8 ϩ / MAIT-cells remains to be defined.NK T cells and MAIT-cells are the only lymphocyte populations to have a restricted TCR repertoire and restricting MHC molecule that is conserved between species. NK T cells are more abundant in mice, whereas MAIT-cells are more numerous in man, representing up to 15% of human CD8 ϩ T cells. Their developmental pathways are distinct. NK T cells are selected, expand and develop their innate-like phenotype, and function before exit from the thymus. They already express the transcription factor ZBTB16, which is crucial for their ready innate/effector functions. 10-12 MAIT-cells are naive and low in number i...

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Doubting the TCR Coreceptor Function of CD8αα

Cited by 171 publications

References 103 publications

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

Regeneration of CD8αβ T Cells from T-cell–Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells

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