Downbeat nystagmus following classical heat stroke

MRI and MR Spectroscopy Features of Heat Stroke: A Case Report

“…Hippocampal involvement is probably the result of circulatory imbalance and hypoxic ischemic event. Midline cerebellum, especially the vestibulocerebellar region was proposed to be more affected by heat stroke upon the downbeat nystagmus, which was the sole clinical finding of cases with heat stroke (14,19). In our case, cytotoxic edema was noted in cerebellar cortices, along the corticofugal fibers, lemniscal pathways and tegmental tracts of the brain stem, in the external capsules, thalami, hippothalami, and hippocampi with acute pansinusitis and bilataral granulomatous otitis.…”

“…Brain lesions in heat stroke on MRI are bilateral and symmetrical in most cases (8). Diffuse cerebellar edema, cortical edema especially in the vascular boundary zone and lesions in the external capsules, hippocampus, thalamus, brain stem and white matter were reported on MRI (1,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Improved Detection of Heat Stroke-Induced Brain Injury by High B-Value Diffusion-Weighted Imaging

“…severe exertion), or a combination of both (2,3). Heat stroke is potentially life-threatening and usually associated with multiple organ failure (1)(2)(3). Central nervous system (CNS) is extremely vulnerable to injury by heat stroke, and is virtually involved in all cases (3)(4)(5)(6).…”

“…The thermal insult could be environmental (classical heat stroke), endogenous (e.g. severe exertion), or a combination of both (2,3). Heat stroke is potentially life-threatening and usually associated with multiple organ failure (1)(2)(3).…”

“…Heat stroke is characterized by elevated core body temperature >40.6C (1,2). The thermal insult could be environmental (classical heat stroke), endogenous (e.g.…”