Downregulated SIRT1 in the CeA is involved in chronic pain-depression comorbidity

Sun, Yi-Man; Shen, Ying; Huang, Hui; Liu, Qiang; Chen, Chen; Ma, Lin-Hui; Wan, Jie; Sun, Yin-Ying; Zhou, Chenghua; Wu, Yuqing

doi:10.1016/j.brainresbull.2021.07.002

Cited by 5 publications

(4 citation statements)

References 55 publications

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“…The amygdala is a brain region involved in pain and emotional-affective states and disorders. One study provided a novel mechanism for elucidating comorbid aversive and depressive symptoms in NP and highlighted that structural and functional neuroplasticity in the amygdala may be important as a promising therapeutic target for comorbid negative emotional-affective disorders in chronic pain ( 67 ). The nucleus accumbens, located at the junction of the basal nucleus and the limbic system, is an important part of the reward pathway and plays an important role in the occurrence and development of pain and depression ( 68 , 69 ), The anterior cingulate cortex has been recognized as a key hub for NP comorbid mood disorder symptoms.…”

Section: Discussionmentioning

confidence: 99%

Research hotspots and trends on neuropathic pain-related mood disorders: a bibliometric analysis from 2003 to 2023

Wang,

Zhuang,

Lin

et al. 2023

Front. Pain Res.

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IntroductionNeuropathic Pain (NP) is often accompanied by mood disorders, which seriously affect the quality of life of patients. This study aimed to analyze the hotspots and trends in NP-related mood disorder research using bibliometric methods and to provide valuable predictions for future research in this field.MethodsArticles and review articles on NP-related mood disorders published from January 2003 to May 2023 were retrieved from the Web of Science Core Collection. We used CiteSpace to analyze publications, countries, institutions, authors, cited authors, journals, cited journals, references, cited references, and keywords. We also analyzed collaborative network maps and co-occurrence network maps.ResultsA total of 4,540 studies were collected for analysis. The number of publications concerning NP-related mood disorders every year shows an upward trend. The United States was a major contributor in this field. The University of Toronto was the most productive core institution. C GHELARDINI was the most prolific author, and RH DWORKIN was the most frequently cited author. PAIN was identified as the journal with the highest productivity and citation rate. The current research hotspots mainly included quality of life, efficacy, double-blind methodology, gabapentin, pregabalin, postherpetic neuralgia, and central sensitization. The frontiers in research mainly focused on the mechanisms associated with microglia activation, oxidative stress, neuroinflammation, and NP-related mood disorders.DiscussionIn conclusion, the present study provided insight into the current state and trends in NP-related mood disorder research over the past 20 years. Consequently, researchers will be able to identify new perspectives on potential collaborators and cooperative institutions, hot topics, and research frontiers in this field.

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Section: Discussionmentioning

confidence: 99%

Research hotspots and trends on neuropathic pain-related mood disorders: a bibliometric analysis from 2003 to 2023

Wang,

Zhuang,

Lin

et al. 2023

Front. Pain Res.

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“…However, there are few reports on the roles of lncRNAs in chronic pain-related depression. In our previous work, we have found that CeA SIRT1 plays a vital role in chronic pain-induced depression ( Zhou et al, 2020 ; Sun et al, 2021 ). Using lncRNA microarray technique, we have identified differentially expressed lncRNAs in the CeA of chronic pain-induced depression rats.…”

Section: Discussionmentioning

confidence: 99%

“…SIRT1, a class-III HDAC, has been found to be involved in chronic pain-associated depression ( Zhou et al, 2020 ; Sun et al, 2021 ). In the current study, the bioinformatic prediction and dual-luciferase reporter assay demonstrated that SIRT1 was a direct target gene of miR-128-3p.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, both clinical and animal experiments have shown that SIRT1 is involved in the development of depression ( Lo Iacono et al, 2015 ; Abe-Higuchi et al, 2016 ; Kim et al, 2016 ; Luo and Zhang, 2016 ). Moreover, our previous studies have demonstrated that in the central nucleus of the amygdala (CeA), a key brain area that regulates both pain and emotional behaviors ( Veinante et al, 2013 ; Neugebauer, 2015 ; Zhu et al, 2019 ), of chronic pain-induced depression rats SIRT1 expression is decreased significantly, while SIRT1 overexpression alleviates the depression-like behaviors associated with chronic pain, indicating that SIRT1 plays an important role in the formation of chronic pain-induced depression ( Zhou et al, 2020 ; Sun et al, 2021 ). However, the upstream mechanisms for SIRT1 to regulate chronic pain-related depression is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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LncRNA-84277 is involved in chronic pain-related depressive behaviors through miR-128-3p/SIRT1 axis in central amygdala

Jiao

Wang

Ding

et al. 2022

Front. Mol. Neurosci.

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Long-term chronic pain can lead to depression. However, the mechanism underlying chronic pain-related depression remains unclear. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase (HDAC). Our previous studies have demonstrated that SIRT1 in the central nucleus of the amygdala (CeA) is involved in the development of chronic pain-related depression. In addition, increasing studies have indicated that long non-coding RNAs (lncRNAs) play a vital role in the pathogenesis of pain or depression. However, whether lncRNAs are involved in SIRT1-mediated chronic pain-related depression remains largely unknown. In this study, we identified that a novel lncRNA-84277 in CeA was the upstream molecule to regulate SIRT1 expression. Functionally, lncRNA-84277 overexpression in CeA significantly alleviated the depression-like behaviors in spared nerve injury (SNI)-induced chronic pain rats, whereas lncRNA-84277 knockdown in CeA induced the depression-like behaviors in naïve rats. Mechanically, lncRNA-84277 acted as a competing endogenous RNA (ceRNA) to upregulate SIRT1 expression by competitively sponging miR-128-3p, and therefore improved chronic pain-related depression-like behaviors. Our findings reveal the critical role of lncRNA-84277 in CeA specifically in guarding against chronic pain-related depression via a ceRNA mechanism and provide a potential therapeutic target for chronic pain-related depression.

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The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk

Sublette,

Daray,

Ganança

et al. 2023

Mol Psychiatry

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Downregulated SIRT1 in the CeA is involved in chronic pain-depression comorbidity

Cited by 5 publications

References 55 publications

Research hotspots and trends on neuropathic pain-related mood disorders: a bibliometric analysis from 2003 to 2023

Research hotspots and trends on neuropathic pain-related mood disorders: a bibliometric analysis from 2003 to 2023

LncRNA-84277 is involved in chronic pain-related depressive behaviors through miR-128-3p/SIRT1 axis in central amygdala

The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk

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