DOX@Ferumoxytol-Medical Chitosan as magnetic hydrogel therapeutic system for effective magnetic hyperthermia and chemotherapy in vitro

Chen, Bo; Xing, Jing; Li, Mingyue; Liu, Yanlong; Ji, Min

doi:10.1016/j.colsurfb.2020.110896

Cited by 46 publications

(21 citation statements)

References 27 publications

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“…As a typical example, a cell apoptosis assay presented that doxorubicin-ferumoxytol-medical chitosan nanoparticles could provide synergistic efficacy in colon carcinoma cell treatment in vitro compared to other therapeutic groups. Heat induction in mice subcutaneous xenografted tumors demonstrated the better heating performance of such MNPs [ 133 , 134 ].…”

Section: Typical Examples Of Magnetic Hyperthermia With Mnpsmentioning

confidence: 99%

Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy

2021

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The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating magnetic field is a promising technique for targeted cancer therapy. The external alternating magnetic field generates heat in the tumor area, which is utilized to kill cancerous cells. Depending on the tumor type and site to be targeted, various types of magnetic nanoparticles, with variable coating materials of different shape and surface charge, have been developed. The tunable physical and chemical properties of magnetic nanoparticles enhance their heating efficiency. Moreover, heating efficiency is directly related with the product values of the applied magnetic field and frequency. Protein corona formation is another important parameter affecting the heating efficiency of MNPs in magnetic hyperthermia. This review provides the basics of magnetic hyperthermia, mechanisms of heat losses, thermal doses for hyperthermia therapy, and strategies to improve heating efficiency. The purpose of this review is to build a bridge between the synthesis/coating of magnetic nanoparticles and their practical application in magnetic hyperthermia.

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Section: Typical Examples Of Magnetic Hyperthermia With Mnpsmentioning

confidence: 99%

Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy

2021

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“…[22][23][24][25] There are different types of nanoparticles, including polymer nanoparticles, liposomes, magnetic nanoparticles, metal nanoparticles, polymer micelles, etc. [26][27][28][29][30] The current research on nanomaterials for the treatment of rheumatoid arthritis can be roughly divided into the following three types: (1) traditional nanomaterials: the drug is encapsulated in a nanocarrier and selectively delivered to the predetermined site of action through a targeted method; (2) using cell membranes to coat nanomaterials to form biomimetic nanomaterials to treat rheumatoid arthritis; (3) nanomaterials have their own inherent characteristics as drugs for the treatment of rheumatoid arthritis (Fig. 1).…”

Section: Different Types Of Nanomaterials Used In the Treatment Of Rhmentioning

confidence: 99%

Application of nanomaterials in the treatment of rheumatoid arthritis

et al. 2021

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“…Similarly, magnetic hydrogels formed by doxorubicin, ferumoxytol and medical chitosan were produced by Chen et al with promising applications in hyperthermia and tumor synergistic treatment. 34 This work shows the simultaneous transport and release of different drugs, as they combine different anticancer agents in a multidrug delivery complex formulation.…”

Section: Hyperthermiamentioning

confidence: 96%

Biomedical applications of magnetic hydrogels

Mañas‐Torres

Gila-Vilchez

Durán

et al. 2021

Magnetic Nanoparticle-Based Hybrid Materials

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Hydrogels are used in biomedical applications thanks to their high-water content, porosity, and their ability to easily modify their properties (mechanical, chemical, microstructure, etc.). Hydrogels are the materials that most resemble the extracellular matrix of mammals. In recent years, magnetic hydrogels have become especially important. These are the result of combining magnetic nanoparticles with different hydrogel matrices. Among its properties, they have the ability to be remotely controlled modifying their physical properties, such as stability, stiffness and temperature (magnetic hyperthermia). Such unique characteristics make magnetic hydrogels very promising in biomedical applications such as, tissue engineering, drug delivery, biosensors, and cancer therapy. At this respect, this chapter focuses on the main biomedical applications of magnetic hydrogels and the most important discoveries on the subject.

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DOX@Ferumoxytol-Medical Chitosan as magnetic hydrogel therapeutic system for effective magnetic hyperthermia and chemotherapy in vitro

Cited by 46 publications

References 27 publications

Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy

Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy

Application of nanomaterials in the treatment of rheumatoid arthritis

Biomedical applications of magnetic hydrogels

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