Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes

Chen, Zhuo; Yuan, Shen-Jun; Li, Ké; Zhang, Quan; Li, Tong‐Fei; An, Hui-Chao; Xu, Hua‐Zhen; Yue, Yuan; Han, Min; Xu, Yunyun; Komatsu, Naoki; Zhao, Li; Chen, Xiao

doi:10.1016/j.jconrel.2020.01.044

Cited by 27 publications

(18 citation statements)

References 32 publications

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“…68 For the rst time, HPG-modied NDs were synthesized by Komatsu et al to increase the solubility of NDs for biomedical applications. The preparation of nanosystems for the delivery of anticancer drugs such as cisplatin 93 and DOX [94][95][96][97][98][99]109 is the main usage of HPG-ND conjugates. The nano-DOX obtained by Zhao and Chen's research team showed promising results for treating the brain tumor glioblastoma.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

“…The nano-DOX obtained by Zhao and Chen's research team showed promising results for treating the brain tumor glioblastoma. [95][96][97][98] Also, the intrinsic uorescence of nanodiamonds can be used to obtain clear uorescence images. 101 HPG was graed onto the surfaces of CNTs via both covalent and noncovalent approaches.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

“… 95,96 In addition, nano-DOX can suppress the transcription factor STAT3, which is the activator of many actions, including apoptosis inhibition in GBM. 97 In another study, this research team indicated that nano-DOX acts by different mechanisms from free DOX on human glioblastoma cells (GC). While DOX-treated GC showed signs of apoptosis, nano-DOX activated autophagy and stimulated the expression and release of HMGB1, which is a prominent member of damage-associated molecular patterns (DAMPs).…”

Section: Nanodiamondsmentioning

confidence: 99%

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Modification of carbon-based nanomaterials by polyglycerol: recent advances and applications

Rafiee

Omidi

2022

RSC Adv.

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Section: Summary and Future Perspectivesmentioning

confidence: 99%

Section: Summary and Future Perspectivesmentioning

confidence: 99%

Section: Nanodiamondsmentioning

confidence: 99%

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Modification of carbon-based nanomaterials by polyglycerol: recent advances and applications

Rafiee

Omidi

2022

RSC Adv.

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“…Yang et al downstream signaling. 44,45 The decreased expression of IFN-β and IL-6 with allicin treatment suggested that allicin could inhibit HCMV activity and reduce the malignant degree of GBM. 46,47 Allicin also inhibited the expression of IL-6 and IFN-β in macrophages, which could inhibit the protumor features of M2 macrophages, as well as their differentiation.…”

Section: Dovepressmentioning

confidence: 99%

<p>Allicin Inhibits Proliferation by Decreasing IL-6 and IFN-β in HCMV-Infected Glioma Cells</p>

Yang

Zhu

et al. 2020

CMAR

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Allicin, an extract of garlic, has antitumor effects in multiple tumor types. However, the efficacy of allicin for treating glioblastoma has not yet been examined. This study examined the antitumor effect of allicin on human cytomegalovirus (HCMV)-infected glioblastoma multiforme (GBM) and its role in cytokine signaling. Materials and Methods: HCMV-infected glioblastoma was modeled by transfection of U87MG glioblastoma cells with HMCV proteins. MTT assay was used to assess the effect of allicin on the proliferation of glioma cells. Western blot analysis was used to detect the effect of allicin on the expression of intermediate-early gene 2 (IE2) and p53. Reverse transcription-quantitative polymerase chain reaction was used to assess and the levels of interleukin (IL)-6 and interferon (IFN)-β. Single cell gel electrophoresis was used to analyze changes in radiotherapy-induced DNA damage. Results: Transfection of the IE2 protein led to decreased p53 expression and increased glioblastoma cell proliferation. Allicin inhibited this proliferation in a dose-and time-dependent manner. An inhibitory effect on cytokine release was observed in GBM cells treated with allicin. After treatment with allicin, p53 levels increased significantly, whereas expression of the inflammatory factors such as IL-6 and IFN-β decreased. U87MG cells treated with allicin and 10 Gy irradiation had increased intracellular DNA damage compared to either treatment alone. Conclusion: Allicin inhibited proliferation of glioblastoma cells in vitro. Allicin also inhibited cytokine release, upregulated p53 activity, and increased the sensitivity of glioblastoma to radiotherapy. These results suggest that allicin is effective against HCMVinfected glioblastomas.

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“…In the follow-up studies, the mechanism of the NDs-related action was attributed to the activation of autophagy [ 176 , 177 ] . In a different study by the same team, the NDs-DOX complex was found to suppress the glioblastoma - astrocyte cross-talk, breaking the chain responsible for acquiring resistance towards various therapies by evading apoptosis [ 178 ] . The same material was also used to evade chemoresistance and reverse cancer-induced immunosuppression in triple-negative breast cancer [ 179 ] .…”

Section: Nanocarriers For the Treatment Of Drug Resistance In Tumorsmentioning

confidence: 99%

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

Benko¹

2020

CDR

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Cancer is one of the biggest healthcare concerns in our century, a disease whose treatment has become even more difficult following reports of drug-resistant tumors. When this happens, chemotherapy treatments fail or decrease in efficiency, leading to catastrophic consequences to the patient. This discovery, along with the fact that drug resistance limits the efficacy of current treatments, has led to a new wave of discovery for new methods of treatment. The use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in cancer. Research in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive targeting. Consequently, these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better targeting. This review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers, including polymeric, viral, lipid-based, metal-based, carbon-based, and magnetic nanocarriers, opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors.

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Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes

Cited by 27 publications

References 32 publications

Modification of carbon-based nanomaterials by polyglycerol: recent advances and applications

Modification of carbon-based nanomaterials by polyglycerol: recent advances and applications

<p>Allicin Inhibits Proliferation by Decreasing IL-6 and IFN-β in HCMV-Infected Glioma Cells</p>

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

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