Doxycycline-Induced Esophagitis

Hatheway, Gerard J.

doi:10.1177/106002808201601116

Cited by 6 publications

(1 citation statement)

References 2 publications

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“…Although frequent serious oesophageal ulcerations has been associated with doxycycline (Hatheway, 1982;Shiff, 1986) none of our study cohort presented/complained of this type of reaction. The incidence rates and intensity of gastrointestinal intolerance may be an important aspect to be monitored if the drug has to be adopted for filarial chemotherapy.…”

Section: Discussionmentioning

confidence: 57%

Hospital-based safety and telerability study to assesss efficacy of oral doxycycline in the treatment of <i> Wuchereria bancrofti infection in north-eastern Tanzania

Makunde¹,

Kamugisha²,

Makunde³

et al. 2009

Tanzania J Hlth Res

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A hospital based open-label clinical trial of 19 apparently healthy adult males with microfilaraemia was conducted to assess safety, tolerability and efficacy of doxycycline on Wuchereria bancrofti. Study individuals were assigned 8 weeks treatment with doxycycline 200 mg daily. The results of different selected tests showed that, the haematological, hepatic, renal and clinical parameters pre-and post-drug administrations were within the normal range for all treated individuals. Clinical adverse events were mild, transient, tolerable and reported in 7/19 (36.8%) of the study cohort. The mf clearance rate was 100% at 12 months post treatment for the 13 individuals who completed the follow up. These findings indicate that, although the drug was administered for a long period, there was no evidence of toxicity to the myocardium, hepatocytes, renal, bone marrow and blood cells, suggesting that an 8-week course of 200 mg/day doxycycline is a safe and tolerable regime for the treatment of Wuchereria bancrofti infections.

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Section: Discussionmentioning

confidence: 57%

Hospital-based safety and telerability study to assesss efficacy of oral doxycycline in the treatment of <i> Wuchereria bancrofti infection in north-eastern Tanzania

Makunde¹,

Kamugisha²,

Makunde³

et al. 2009

Tanzania J Hlth Res

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Pill‐Induced Esophageal Injury

Young

Kikendall

2012

The Esophagus

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Medication-Induced Oesophageal Injury

Bott

McCallum

1986

Medical Toxicology

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This is a review of the 127 cases of drug-induced oesophagitis reported in the English language literature since 1970. The most common symptoms reported were retrosternal pain, odynophagia, and dysphagia. Most cases were self-limited and symptoms resolved in 7 to 10 days with symptomatic therapy. Occasionally, severe odynophagia or dysphagia necessitated hospitalisation. Emepronium bromide, tetracycline and its derivatives, potassium chloride, and quinidine account for 89% of the reported cases of medication-induced oesophageal injury. 14 other medications have been reported to injure the oesophagus. Serious sequelae, including death, have been linked to potassium-induced oesophageal injury. With other medications, however, serious complications were rare. The diagnostic study of choice is endoscopy; an air-contrast barium swallow may also detect the often subtle mucosal abnormalities produced by medication injury. However, the diagnosis does not require confirmation by radiographical or endoscopic means in all cases, and the history alone may be sufficient to make the diagnosis in uncomplicated cases. Medication-induced oesophageal injury is preventable if pills are taken with an adequate amount of fluid and if the practice of taking medications immediately before bedtime is avoided.

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Doxycycline-Induced Esophagitis

Cited by 6 publications

References 2 publications

Hospital-based safety and telerability study to assesss efficacy of oral doxycycline in the treatment of <i> Wuchereria bancrofti infection in north-eastern Tanzania

Hospital-based safety and telerability study to assesss efficacy of oral doxycycline in the treatment of <i> Wuchereria bancrofti infection in north-eastern Tanzania

Pill‐Induced Esophageal Injury

Medication-Induced Oesophageal Injury

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