Doxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial

Peuchant, Olivia; Lhomme, Édouard; Martinet, P.; Grob, Anne; Bernier, C.; Gibaud, Sophie; Hen, Isabelle Le; Naour, Erwan Le; Trignol-Viguier, Nathalie; Lanotte, Philippe; Lefèbvre, Philippe; Vachée, Anne; Girard, Thomas; Bebear, Cécile; Ghezzoul, Bellabes; Roussillon, Caroline; Krêt, Marion; Barbeyrac, Bertille de; Ouziel-Duretz, Catherine; Poudens, Béatrice; Brun, Raquel; Jouvert, Sophie; Tesson, Aurore; Carrière, Jennifer; Diaz, Marie; Forget, Camille; Ahano-Ducourneau, France; Van, Delphine Ha; Robert, Pauline; Brun, Fabienne; Lhospital, Estelle; Bardou, Julie; Guegan, Annaïg; Moura, Sandy Ramloll; Leriche, Céline; Cussy, Alix De; Malfait, Marlène; Rychen, Charlotte; Kugeler, Audrey; Barriere, Lisa; Gutierrez, Laura; Robert, Jean-Luc; Saule, Julie; Bergamaschi, Viviana; Soltana, Sana Ben; Aymar-Moulene, Dominique; Lecompte, Anne-Sophie; Gregoire, Antoine; Naccache, Marie-Astrid; Crombe, Pauline; Bulot, Christine; Rolland, Anne-Laure; Blin-Zbiegiel, Elisabeth; Boissinot, Mélanie; Joly, Bruno; Dubreuil, Anne; Mathieu, Camille; Pragout, David; Zaffreya, Sophie; Touati, Arabella; Balcon, Carla; Perry, Frederic; Turuban, Christelle; Rapin, Sabine; Pastor, Christine; Cavellec, Morane; Manyari, Ernesto Paredes; Albane, Soria; Dernivoix, Katy; Trouillet, Camille; Ghiringelli, Eva; Pantin, Karen; Garreau, Damien; Galet, Jérôme

doi:10.1016/s1473-3099(22)00148-7

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Pathogen-directed Treatment Of Specific Sexually Transmitted...1

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Cited by 8 publications

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“… 53 In addition, recent trials have shown a higher efficacy of doxycycline as compared to azithromycin for the treatment of rectal C. trachomatis infection in MSM and women. 54 , 55 Concurrent treatment of rectal infection in women is important as auto-inoculation of cervical infection may occur resulting in persistent infection. In addition, rectal infections may remain untreated in MSM and women posing an increased risk for HIV transmission.…”

Section: Pathogen-directed Treatment Of Specific Sexually Transmitted...mentioning

confidence: 99%