Abstract:Gene therapy holds great promise as an effective treatment for many diseases of genetic origin. Gene therapy works by employing cationic polymers, liposomes, and nanoparticles to condense DNA into polyplexes via electronic interactions. Then, a therapeutic gene is introduced into target cells, thereby restoring or changing cellular function. However, gene transfection efficiency remains low in vivo due to high protein binding, poor targeting ability, and substantial endosomal entrapment. Artificial sheaths con… Show more
Functional polymer nanoparticles deliver CRISPR-Cas9 into tumours to efficiently and simultaneously cut off two different genes to manipulate glutamine metabolism for fighting cancers.
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