Draft genome sequence of Staphylococcus agnetis 3682, the producing strain of the broad-spectrum lantibiotic agneticin 3682

Fagundes, Patrícia Carlin; Francisco, Márcia Silva; Santos, Ilana Nascimento Sousa; Marques-Bastos, Selda Loase Salustiano; Paz, Juliana Aparecida Souza da; Albano, Rodolpho Mattos; Bastos, Maria do Carmo de Freire

doi:10.1016/j.jgar.2019.08.014

Cited by 4 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, the potential application of bacteriocin synthesized by S. agnetis has been discussed [ 123 , 124 ]. S. agnetis strain 3682 (previously S. hyicus 3682) was discovered to produce a bacteriocin, named agneticin 3682, that manifested a broad spectrum of antimicrobial action [ 123 ]. It was the first bacteriocin described in this staphylococcal species.…”

Section: Antimicrobial Resistance In S Agnetismentioning

confidence: 99%

“…The agneticin-producing isolate showed a marked inhibitory activity against multidrug- and methicillin-resistant S. aureus (MRSA). Agneticin 3682 may offer a new strategy to fight against clinical MRSA isolates [ 123 ]. Similarly, the S. agnetis strain 4S97B isolated from goat and sheep milk was reported to produce a bacteriocin able to inhibit the growth of Listeria monocytogenes .…”

Section: Antimicrobial Resistance In S Agnetismentioning

confidence: 99%

See 1 more Smart Citation

A Review of Current Knowledge on Staphylococcus agnetis in Poultry

Szafraniec

Szeleszczuk

Dolka

2020

Animals

View full text Add to dashboard Cite

This review aims to summarize recent discoveries and advancements regarding the characteristics of Staphylococcus agnetis (S. agnetis) and its role in poultry pathology. S. agnetis is an emerging pathogen that was primarily associated with mastitis in dairy cattle. After a presumed host jump from cattle to poultry, it was identified as a pathological agent in broiler chickens (Gallus gallus domesticus), causing lameness induced by bacterial chondronecrosis with osteomyelitis (BCO), septicemia, and valvular endocarditis. Economic and welfare losses caused by lameness are global problems in the poultry industry, and S. agnetis has been shown to have a potential to induce high incidences of lameness in broiler chickens. S. agnetis exhibits a distinct repertoire of virulence factors found in many different staphylococci. It is closely related to S. hyicus and S. chromogenes, hence infections caused by S. agnetis may be misdiagnosed or even undiagnosed. As there are very few reports on S. agnetis in poultry, many facts about its pathogenesis, epidemiology, routes of transmission, and the potential impacts on the poultry industry remain unknown.

show abstract

Section: Antimicrobial Resistance In S Agnetismentioning

confidence: 99%

Section: Antimicrobial Resistance In S Agnetismentioning

confidence: 99%

A Review of Current Knowledge on Staphylococcus agnetis in Poultry

Szafraniec

Szeleszczuk

Dolka

2020

Animals

View full text Add to dashboard Cite

show abstract

“…Over the years, further staphylococcal class-I lantibiotics have been identified that are variants of or closely related to epidermin: 1V,6L-epidermin from S. epidermidis V1 and V301 [Bierbaum et al, 1996], staphylococcin T (identical to gallidermin) from Staphylococcus cohnii T [Furmanek et al, 1999], staphylococcin Au-26/Bsa/aureodermin [Scott et al, 1992;Daly et al, 2010;Joo et al, 2011] and BacCH91 [Wladyka et al, 2013] from S. aureus, and agneticin 3682 (formerly hyicin 3682) isolated from Staphylococcus agnetis (formerly Staphylococcus hyicus) [Fagundes et al, 2011;Fagundes et al, 2019].…”

Section: Lanthipeptidesmentioning

confidence: 99%

Secondary Metabolites Governing Microbiome Interaction of Staphylococcal Pathogens and Commensals

et al. 2021

View full text Add to dashboard Cite

Various Staphylococcus species colonize skin and upper airways of warm-blooded animals. They compete successfully with many other microorganisms under the hostile and nutrient-poor conditions of these habitats using mechanisms that we are only beginning to appreciate. Small-molecule mediators, whose biosynthesis requires complex enzymatic cascades, so-called secondary metabolites, have emerged as crucial components of staphylococcal microbiome interactions. Such mediators belong to a large variety of compound classes and several of them have attractive properties for future drug development. They include, for instance, bacteriocins such as lanthipeptides, thiopeptides, and fibupeptides that inhibit bacterial competitor species; signaling molecules such as thiolactone peptides that induce or inhibit sensory cascades in other bacteria; or metallophores such as staphyloferrins and staphylopine that scavenge scant transition metal ions. For some secondary metabolites such as the aureusimines, the exact function remains to be elucidated. How secondary metabolites shape the fitness of Staphylococcus species in the complex context of other microbial and host defense factors remains a challenging field of future research. A detailed understanding will help to harness staphylococcal secondary metabolites for excluding the pathogenic species Staphylococcus aureus from the nasal microbiomes of at-risk patients, and it will be instrumental for the development of advanced anti-infective interventions.

show abstract