Draft Genome Sequences of 10 Multidrug-Resistant Escherichia coli Strains Isolated from Piglets in Peru

Álvarez, Luis Fernando Arboleda; Carhuaricra, Denis; Palomino-Farfán, Joel André; Calle, Sonia E.; Maturrano, Lenin; Siuce, M Juan

doi:10.1128/mra.00706-22

Cited by 1 publication

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“…The data of 10 Peruvian porcine E. coli strains included in this analysis are available as raw reads in SRA and GenBank [54]. The details of the isolation and sequencing methodologies have previously been published [54], but are briefly detailed here.…”

Section: Isolation Sequencing and Genome Sequencesmentioning

confidence: 99%

Genomic Profiling of Multidrug-Resistant Swine Escherichia coli and Clonal Relationship to Human Isolates in Peru

Alvarez,

Carhuaricra,

Palomino-Farfan

et al. 2023

Antibiotics

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The misuse of antibiotics is accelerating antimicrobial resistance (AMR) in Escherichia coli isolated from farm animals. The genomes of ten multidrug-resistant (MDR) E. coli isolates from pigs were analyzed to determine their sequence types, serotypes, virulence, and AMR genes (ARGs). Additionally, the relationship was evaluated adding all the available genomes of Peruvian E. coli from humans using the cgMLST + HierCC scheme. Two aEPEC O186:H11-ST29 were identified, of which H11 and ST29 are reported in aEPEC isolates from different sources. An isolate ETEC-O149:H10-ST100 was identified, considered a high-risk clone that is frequently reported in different countries as a cause of diarrhea in piglets. One ExPEC O101:H11-ST167 was identified, for which ST167 is an international high-risk clone related to urinary infections in humans. We identified many ARGs, including extended-spectrum β-lactamase genes, and one ETEC harboring the mcr-1 gene. CgMLST + HierCC analysis differentiated three clusters, and in two, the human isolates were grouped with those of swine in the same cluster. We observed that Peruvian swine MDR E. coli cluster with Peruvian E. coli isolates from healthy humans and from clinical cases, which is of great public health concern and evidence that AMR surveillance should be strengthened based on the One Health approach.

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Section: Isolation Sequencing and Genome Sequencesmentioning

confidence: 99%

Genomic Profiling of Multidrug-Resistant Swine Escherichia coli and Clonal Relationship to Human Isolates in Peru

Alvarez,

Carhuaricra,

Palomino-Farfan

et al. 2023

Antibiotics

Self Cite

View full text Add to dashboard Cite

show abstract

Draft Genome Sequences of 10 Multidrug-Resistant Escherichia coli Strains Isolated from Piglets in Peru

Abstract: Pathogenic Escherichia coli frequently causes diarrhea on pig farms. Here, we report the draft genome sequences of 10 strains of multidrug-resistant E. coli isolated from piglets.

Cited by 1 publication

References 8 publications

Genomic Profiling of Multidrug-Resistant Swine Escherichia coli and Clonal Relationship to Human Isolates in Peru

Genomic Profiling of Multidrug-Resistant Swine Escherichia coli and Clonal Relationship to Human Isolates in Peru

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