Draft Genome Sequences of Two Highly Erythromycin-Resistant Streptococcus gallolyticus subsp.
 gallolyticus
 Isolates Containing a Novel Tn
 916
 -Like Element, Tn
 6331

Kambarev, Stanimir; Pecorari, Frédéric; Corvec, Stéphane

doi:10.1128/genomea.00226-17

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…Two of these isolates, NTS31301958 and NTS31307655, displayed different Tn6263 right-end amplicons (Figure S4a) and the only indistinguishable PFGE profiles (Figure S4b). Subsequent WGS 12 revealed that they contain another novel element, named Tn6331, which is highly related to Tn6263 (Figure S4c). Collectively, these results suggest that: (i) Tn6263 and/or related transposons are highly prevalent among the tested genetically heterogeneous Sgg isolates; (ii) they are the major ermB-carrying elements in the studied collection and; (iii) an integration hot spot for these elements is present in the chromosome of Sgg.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Novel Tn916-like elements confer aminoglycoside/macrolide co-resistance in clinical isolates of Streptococcus gallolyticus ssp. gallolyticus

Kambarev

Pecorari

Corvec

2018

Journal of Antimicrobial Chemotherapy

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Section: Resultsmentioning

confidence: 99%

“…WGS is explained elsewhere. 11,12 Comparative analysis software and visualization is described at the end of the first Supplementary data file.…”

Section: Wgs and Comparative Analysismentioning

confidence: 99%

Novel Tn916-like elements confer aminoglycoside/macrolide co-resistance in clinical isolates of Streptococcus gallolyticus ssp. gallolyticus

Kambarev

Pecorari

Corvec

2018

Journal of Antimicrobial Chemotherapy

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“…The pangenome is increasing at a high rate entailing numerous unique genes for each new strain added (Hinse et al, 2011b ). Nearly all SBSEC genomes reveal horizontal gene transfer relating to general carbohydrate metabolism, capsular polysaccharides, antimicrobial resistance or tannase as the key discriminator of SGG (Rusniok et al, 2010 ; Hinse et al, 2011b ; Lin et al, 2011b ; Jans et al, 2013 ; Papadimitriou et al, 2014 ; Kambarev and Caté, 2015 ; Grimm et al, 2017a ; Kambarev et al, 2017 ). Natural competence operons and pseudopilus identified in SII and SGG likely contribute to the success of horizontal gene transfer and thus to niche adaptation (Rusniok et al, 2010 ; Lin et al, 2011b ; Morrison et al, 2013 ; Jans et al, 2016 ).…”

Section: Transmission and Niche Adaption Of Sbsec Membersmentioning

confidence: 99%

The Road to Infection: Host-Microbe Interactions Defining the Pathogenicity of Streptococcus bovis/Streptococcus equinus Complex Members

Jans¹,

Boleij²

2018

Front. Microbiol.

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The Streptococcus bovis/Streptococcus equinus complex (SBSEC) comprises several species inhabiting the animal and human gastrointestinal tract (GIT). They match the pathobiont description, are potential zoonotic agents and technological organisms in fermented foods. SBSEC members are associated with multiple diseases in humans and animals including ruminal acidosis, infective endocarditis (IE) and colorectal cancer (CRC). Therefore, this review aims to re-evaluate adhesion and colonization abilities of SBSEC members of animal, human and food origin paired with genomic and functional host-microbe interaction data on their road from colonization to infection. SBSEC seem to be a marginal population during GIT symbiosis that can proliferate as opportunistic pathogens. Risk factors for human colonization are considered living in rural areas and animal-feces contact. Niche adaptation plays a pivotal role where Streptococcus gallolyticus subsp. gallolyticus (SGG) retained the ability to proliferate in various environments. Other SBSEC members have undergone genome reduction and niche-specific gene gain to yield important commensal, pathobiont and technological species. Selective colonization of CRC tissue is suggested for SGG, possibly related to increased adhesion to cancerous cell types featuring enhanced collagen IV accessibility. SGG can colonize, proliferate and may shape the tumor microenvironment to their benefit by tumor promotion upon initial neoplasia development. Bacteria cell surface structures including lipotheichoic acids, capsular polysaccharides and pilus loci (pil1, pil2, and pil3) govern adhesion. Only human blood-derived SGG contain complete pilus loci and other disease-associated surface proteins. Rumen or feces-derived SGG and other SBSEC members lack or harbor mutated pili. Pili also contribute to binding to fibrinogen upon invasion and translocation of cells from the GIT into the blood system, subsequent immune evasion, human contact system activation and collagen-I-binding on damaged heart valves. Only SGG carrying complete pilus loci seem to have highest IE potential in humans with significant links between SGG bacteremia/IE and underlying diseases including CRC. Other SBSEC host-microbe combinations might rely on currently unknown mechanisms. Comparative genome data of blood, commensal and food isolates are limited but required to elucidate the role of pili and other virulence factors, understand pathogenicity mechanisms, host specificity and estimate health risks for animals, humans and food alike.

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“…One study on infant infection reported that the SGG strain was susceptible to penicillin, ceftriaxone, gentamicin and vancomycin [17]. Single SGG strains resistant to erythromycin have emerged [45].…”

Section: Streptococcus Gallolyticus Subsp Gallolyticus (Sgg)mentioning

confidence: 99%

Pathogenicity and drug resistance of animal streptococci responsible for human infections

Glajzner

Szewczyk

Szemraj

2021

Journal of Medical Microbiology

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Bacteria of the genus Streptococcus , earlier considered typically animal, currently have also been causing infections in humans. It is necessary to make clinicians aware of the emergence of new species that may cause the development of human diseases. There is an increasing frequency of isolation of streptococci such as S. suis , S. dysgalactiae , S. iniae and S. equi from people. Isolation of Streptococcus bovis/Streptococcus equinus complex bacteria has also been reported. The streptococcal species described in this review are gaining new properties and virulence factors by which they can thrive in new environments. It shows the potential of these bacteria to changes in the genome and the settlement of new hosts. Information is presented on clinical cases that concern streptococcus species belonging to the groups Bovis, Pyogenic and Suis. We also present the antibiotic resistance profiles of these bacteria. The emerging resistance to β-lactams has been reported. In this review, the classification, clinical characteristics and antibiotic resistance of groups and species of streptococci considered as animal pathogens are summarized.

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Draft Genome Sequences of Two Highly Erythromycin-Resistant Streptococcus gallolyticus subsp. gallolyticus Isolates Containing a Novel Tn 916 -Like Element, Tn 6331

Cited by 6 publications

References 20 publications

Novel Tn916-like elements confer aminoglycoside/macrolide co-resistance in clinical isolates of Streptococcus gallolyticus ssp. gallolyticus

Novel Tn916-like elements confer aminoglycoside/macrolide co-resistance in clinical isolates of Streptococcus gallolyticus ssp. gallolyticus

The Road to Infection: Host-Microbe Interactions Defining the Pathogenicity of Streptococcus bovis/Streptococcus equinus Complex Members

Pathogenicity and drug resistance of animal streptococci responsible for human infections

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