Draft Whole-Genome Sequence of the Biocontrol Agent
            <i>Trichoderma harzianum</i>
            T6776

Baroncelli, Riccardo; Piaggeschi, Giulia; Fiorini, Lisa; Bertolini, Edoardo; Zapparata, Antonio; Pè, Mario Enrico; Sarrocco, Sabrina; Vannacci, Giovanni

doi:10.1128/genomea.00647-15

Cited by 55 publications

(52 citation statements)

References 17 publications

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“…Overall, 10,944 protein-coding genes were predicted. Analysis with WolfPSORT ( 9 ) revealed that 1,356 predicted proteins (12.39% of the proteome) contain secretion signal peptides; those values are comparable to what has been reported for other Trichoderma genomes ( 12 ). A first comparative analysis within Trichoderma spp.…”

Section: Genome Announcementsupporting

confidence: 68%

Draft Whole-Genome Sequence of Trichoderma gamsii T6085, a Promising Biocontrol Agent of Fusarium Head Blight on Wheat

et al. 2016

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Trichoderma gamsii T6085 is a promising beneficial isolate whose effects consist of growth inhibition of the main agents causing Fusarium head blight, reduction of mycotoxin accumulation, competition for wheat debris, and reduction of the disease in both the lab and the field. Here, we present the first genome assembly of a T. gamsii isolate, providing a useful platform for the scientific community.

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Section: Genome Announcementsupporting

confidence: 68%

Draft Whole-Genome Sequence of Trichoderma gamsii T6085, a Promising Biocontrol Agent of Fusarium Head Blight on Wheat

et al. 2016

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“…To explore gene family evolution in C. dendroides, we aligned its coding sequences (CDSs) with those of C. protrusum and 15 other representative fungi downloaded from the NCBI: M. perniciosa [18], Pyricularia oryzae [42], five Trichoderma (T. virens [43], T. reesei [26], T. koningii (https://www.ncbi. nlm.nih.gov/genome/?term=Trichoderma++koningii), T. guizhouense (https://www.ncbi.nlm.nih.gov/ genome/?term=Trichoderma++guizhouense), and T. harzianum [44]), three Neurospora (N. terricola [45], N. tetrasperma [46], and N. crassa [47]), two Cordyceps (Cor. militaris [48] and Cor.…”

Section: Comparative and Evolutionary Analysismentioning

confidence: 99%

“…T. guizhouense (https://www.ncbi.nlm.nih.gov/genome/?term=Trichoderma++guizhouense), and T. harzianum [44]), three Neurospora (N. terricola [45], N. tetrasperma [46], and N. crassa [47]), two Cordyceps (Cor. militaris [48] and Cor.…”

Section: Comparative and Evolutionary Analysismentioning

confidence: 99%

Genomic Features of Cladobotryum dendroides, Which Causes Cobweb Disease in Edible Mushrooms, and Identification of Genes Related to Pathogenicity and Mycoparasitism

Liu

Peng

et al. 2020

Pathogens

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Cladobotryum dendroides, which causes cobweb disease in edible mushrooms, is one of the major fungal pathogens. Our previous studies focused on the genetic and morphological characterization of this fungus, as well as its pathogenicity and the identification of appropriate fungicides. However, little is known about the genome characters, pathogenic genes, and molecular pathogenic mechanisms of C. dendroides. Herein, we reported a high-quality de novo genomic sequence of C. dendroides and compared it with closely-related fungi. The assembled C. dendroides genome was 36.69 Mb, consisting of eight contigs, with an N50 of 4.76 Mb. This genome was similar in size to that of C. protrusum, and shared highly conserved syntenic blocks and a few inversions with C. protrusum. Phylogenetic analysis revealed that, within the Hypocreaceae, Cladobotryum was closer to Mycogone than to Trichoderma, which is consistent with phenotypic evidence. A significant number of the predicted expanded gene families were strongly associated with pathogenicity, virulence, and adaptation. Our findings will be instrumental for the understanding of fungi–fungi interactions, and for exploring efficient management strategies to control cobweb disease.

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“…The study of genomic regions is an important tool for providing a global view of the important genes and regulatory regions of a genome [24, 31]. The genomes of a few strains of T. harzianum are available [32, 33]. A complete genome draft sequenced in 1572 scaffolds is available for T. harzianum T6776 [32]; however, little is known about the ThIOC3844 genome, and as it is a strain with potential for hydrolytic enzymes, more genomic information regarding CAZyme sequences is needed.…”

Section: Discussionmentioning

confidence: 99%

“…The genomes of a few strains of T. harzianum are available [32, 33]. A complete genome draft sequenced in 1572 scaffolds is available for T. harzianum T6776 [32]; however, little is known about the ThIOC3844 genome, and as it is a strain with potential for hydrolytic enzymes, more genomic information regarding CAZyme sequences is needed. In this study, our strategy was to use large genomic regions and integrate these data with other genetic information.…”

Section: Discussionmentioning

confidence: 99%

“Integrative Genomic Analysis for the Bioprospection of Regulators and Accessory Enzymes Associated with Cellulose Degradation in a Filamentous Fungus (Trichoderma harzianum)”

Filho¹,

Horta

Santos

et al. 2019

Preprint

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27Background: Unveiling fungal genome structure and function reveals the potential 28 biotechnological use of fungi. Trichoderma harzianum is a powerful CAZyme-producing 29 fungus. We studied the genomic regions in T. harzianum IOC3844 containing CAZyme 30 genes, transcription factors and transporters. 31Results: We used bioinformatics tools to mine the T. harzianum genome for potential 32 genomics, transcriptomics, and exoproteomics data and coexpression networks. The DNA 33 was sequenced by PacBio SMRT technology for multi-omics data analysis and integration. In 34 total, 1676 genes were annotated in the genomic regions analyzed; 222 were identified as 35CAZymes in T. harzianum IOC3844. When comparing transcriptome data under cellulose or 36 glucose conditions, 114 genes were differentially expressed in cellulose, with 51 CAZymes. 37 CLR2, a transcription factor physically and phylogenetically conserved in T. harzianum spp., 38 was differentially expressed under cellulose conditions. The genes induced/repressed under 39 cellulose conditions included those important for plant biomass degradation, including CIP2 40 of the CE15 family and a copper-dependent LPMO of the AA9 family. 41 Conclusions:Our results provide new insights into the relationship between genomic 42 organization and hydrolytic enzyme expression and regulation in T. harzianum IOC3844. Our 43 results can improve plant biomass degradation, which is fundamental for developing more 44 efficient strains and/or enzymatic cocktails for the production of hydrolytic enzymes. 45

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Draft Whole-Genome Sequence of the Biocontrol Agent Trichoderma harzianum T6776

Cited by 55 publications

References 17 publications

Draft Whole-Genome Sequence of Trichoderma gamsii T6085, a Promising Biocontrol Agent of Fusarium Head Blight on Wheat

Draft Whole-Genome Sequence of Trichoderma gamsii T6085, a Promising Biocontrol Agent of Fusarium Head Blight on Wheat

Genomic Features of Cladobotryum dendroides, Which Causes Cobweb Disease in Edible Mushrooms, and Identification of Genes Related to Pathogenicity and Mycoparasitism

“Integrative Genomic Analysis for the Bioprospection of Regulators and Accessory Enzymes Associated with Cellulose Degradation in a Filamentous Fungus (Trichoderma harzianum)”

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