2011
DOI: 10.1016/j.ejso.2011.07.010
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Dramatic dietary fat reduction is feasible for breast cancer patients: Results of the randomised study, WINS (UK) – Stage 1

Abstract: Demonstrating such feasibility is a key step towards defining diet's role in the secondary prevention of breast cancer.

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Cited by 16 publications
(7 citation statements)
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“…Water may play a role in the removal of cellular carcinogens as chronic dehydration may alter the intracellular water concentration, affect the enzymatic activity in metabolic regulations, and inhibit removal of carcinogens from cells (25). The relationship between oil or fat intake and BC is unclear; however, there is evidence that lower fat intake reduces the concentration of bioavailable serum sex hormones (26,27), which are the main risk factors for BC. Similarly, worldwide sugar consumption has increased threefold in the last 50 years (28).…”
Section: Discussionmentioning
confidence: 99%
“…Water may play a role in the removal of cellular carcinogens as chronic dehydration may alter the intracellular water concentration, affect the enzymatic activity in metabolic regulations, and inhibit removal of carcinogens from cells (25). The relationship between oil or fat intake and BC is unclear; however, there is evidence that lower fat intake reduces the concentration of bioavailable serum sex hormones (26,27), which are the main risk factors for BC. Similarly, worldwide sugar consumption has increased threefold in the last 50 years (28).…”
Section: Discussionmentioning
confidence: 99%
“…Breast cancer recurrence was reduced by 24% (HR, 0.76; 95% CI, 0.60‐0.98) compared with controls, an effect that was even more pronounced in estrogen receptor‐negative patients in secondary subset analyses. The WINS intervention was implemented in the United Kingdom on a much smaller scale and was successful in reducing dietary fat, but data on other endpoints were not collected . The second large dietary intervention study, the Women's Healthy Eating and Living (WHEL) study, had a similar design but randomized 3088 women who were within 4 years of a diagnosis with early stage breast cancer to a 4‐year intervention that promoted 5 servings of fruits and vegetables per day through mailed print educational materials versus an intervention that promoted 10 servings of fruits and vegetables per day (30 g/day of fiber) combined with a low‐fat diet (15%‐20% of energy from fat) through mailed print materials, group classes, and telephone counseling .…”
Section: What Are the Current Guidelines?mentioning
confidence: 99%
“…In Asia, breast cancer has also been reported as the most common cancer among women and the second leading cause of death (12.8% of all cancer) (Ferlay et al, 2013). The role of diets is implicated in incidence of breast cancer (Parry et al, 2011). There was some evidences that the dietary intake of subjects in developing countries needs improvement such as fat intake should be changed to reduce risk of developing breast cancer (Esmaillzadeh and Azadbakht, 2008).…”
Section: Suwit Duangmanomentioning
confidence: 99%