Dramatic Enhancement of Catalytic Activity in an Ionic Liquid: Highly Practical Friedel?Crafts Alkenylation of Arenes with Alkynes Catalyzed by Metal Triflates.

Abstract

flates. -The application of hydrophobic ionic liquids as solvent significantly increases the catalytic activity of metal triflates in the Friedel-Crafts alkenylation of arenes (I) and (IV) with alkynes (II). Good results are also obtained for the alkenylation of electron-deficient alkynes like (Ic) and (Id). The method is successfully applied to intramolecular alkenylation reactions as demonstrated in the cyclization of aryl alkynoates (VII) as well as propiolic amide (IX). -(SONG*, C. E.; JUNG, D.-U.; CHOUNG, S. Y.; ROH, E.