2013
DOI: 10.1128/cvi.00221-13
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Dried Blood as an Alternative to Plasma or Serum for Trypanosoma cruzi IgG Detection in Screening Programs

Abstract: c Trypanosoma cruzi serological screening is recommended for people potentially exposed to this parasite in countries where Trypanosoma cruzi is endemic and those where it is not endemic. Blood samples on filter paper may be a practical alternative to plasma/serum for antibody detection. Using the Architect Chagas assay, we detected the presence of IgG against T. cruzi in matched serum and dried blood spots (DBS) collected from 147 patients residing in Madrid, Spain, who had potential previous exposure to T. c… Show more

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Cited by 20 publications
(36 citation statements)
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“…Their overall results (26)(27)(28) suggest that the Architect Chagas is a highly suitable assay for the diagnosis of chronic T. cruzi infection, and its use as a single technique for routine testing in high-prevalence areas has already been recommended (26). In contrast to what is proposed here, a reduction from 1 to 0.88 in the CO value has been recommended, but only when blood samples on filter paper are used (28).…”
Section: Discussionmentioning
confidence: 48%
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“…Their overall results (26)(27)(28) suggest that the Architect Chagas is a highly suitable assay for the diagnosis of chronic T. cruzi infection, and its use as a single technique for routine testing in high-prevalence areas has already been recommended (26). In contrast to what is proposed here, a reduction from 1 to 0.88 in the CO value has been recommended, but only when blood samples on filter paper are used (28).…”
Section: Discussionmentioning
confidence: 48%
“…Other authors have evaluated the Architect Chagas using different populations or sample conditions (26)(27)(28). Their overall results (26)(27)(28) suggest that the Architect Chagas is a highly suitable assay for the diagnosis of chronic T. cruzi infection, and its use as a single technique for routine testing in high-prevalence areas has already been recommended (26).…”
Section: Discussionmentioning
confidence: 99%
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“…On the other hand, the hypothesis-driven targeted approach, known as multiple reaction monitoring (MRM; also known as selective reaction monitoring), provides for sensitive and robust quantification of pre-selected proteins67. Both approaches have been widely used for quantitative analysis of proteins in various complex sample matrices including Dried Blood Spots (DBS) and serum89101112.…”
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confidence: 99%