This manuscript corresponds to exploratory research carried out to evaluate and define the operating parameters for applying osmotic dehydration (OD) as pretreatment for efficiency improvement in the convective drying of cassava bagasse, providing a methodology to apply these combined techniques, not only for cassava bagasse but also to serve as a reference for its use in other high-moisture agro-industrial residues. Operating factors significant for moisture loss during OD were determined through sieving analysis. Adequate levels and operating conditions were determined for OD and subsequent drying (osmotic agent concentration, solution-to-sample ratio, agitation speed, immersion time, required draining mesh, draining time, drying temperature, and drying air speed). It was established that an osmotic treatment was able to reduce the moisture of cassava bagasse from 87.7% to 28.94% and subsequent drying time by approximately 38.8%. These results allow the use of these combined techniques for drying cassava bagasse, which in turn, open a research agenda for its application in other agro-industrial residues, contributing to its handling, revaluation, and development of a sustainable agro-industry.