Dried human amniotic membrane as an antiadherent layer for intraperitoneal placing of polypropylene mesh in rats

Abstract

Dried irradiated HAM does not prevent adhesion formation in intraabdominal peritoneal onlay PP mesh repair in rats. Any use of this biomaterial in adhesion prophylaxis must be undertaken respecting graft cell viability as much as possible.

Amniotic Membrane-Coated Polypropylene Mesh for the Repair of Incisional Hernia: An Experimental Study In a Rat Model of Abdominal Wall Defect

“…However, there are limited studies on the use of AM in reconstruction of abdominal wall, all of which were experimental animal studies with conflicting outcomes (6,(25)(26)(27). The majority of these studies showed that AM is an effective antiadhesive barrier in polypropylene mesh repair of abdominal wall hernia (6,25,26). polypropylene mesh alone for the correction of abdominal wall defect in rats.It was found that although AM application did not alter the formation of adhesions after the first week of operation, it accelerated the healing as shown by increased inflammation and angiogenesis activity.…”

“…Further clinical studies should be conducted in order to confirm the study findings and to prove the clinical effectiveness of AM as an antiadhesive barrier so that it can 6 Iran Red Crescent Med J. In Press(In Press):e62788.…”

“…Amniotic Membrane induces fibrosis, epithelization, and neovascularization. It also has antiviral and antimicrobial effects, and decreases inflammation (6,19,20). Therefore, it can be used as an anti-adherent layer for polypropylene mesh in repair of abdominal wall defects.…”

“…Particularly in cases with large tissue loss, polypropylene mesh comes in contact with the intraabdominal tissues, causing the adhesions, and leading to intestinal obstruction or fistulas (6). Although many alternative materials and methods for repair of abdominal wall defects were suggested in the literature, such as use of omentum, peritoneum, biological materials, chemicals, stretch films, etc., the ideal material for preventing intraabdominal adhesions is yet to be defined (7)(8)(9)(10)(11)(12)(13)(14).…”

“…Although many alternative materials and methods for repair of abdominal wall defects were suggested in the literature, such as use of omentum, peritoneum, biological materials, chemicals, stretch films, etc., the ideal material for preventing intraabdominal adhesions is yet to be defined (7)(8)(9)(10)(11)(12)(13)(14). centa, is an avascular matrix with a basement membrane and a monolayer of epithelial cells without major histocompatibility complex antigens (6). It has been known that AM, can be used for reconstruction of various tissues (15)(16)(17)(18).…”