Dried Matrix Spots in Forensic Toxicology

Abstract

Dried matrix spots (DMS) has gained the attention of different professionals in different fields, including toxicology. Investigations have been carried out in order to assess the potential of using DMS for the analysis of illicit substances, the main interest of forensic toxicologists. This technique uses minimal volumes of samples and solvents, resulting in simple and rapid extraction procedures. Furthermore, it has proved to increase analyte stability, improving storage and transportation. However, DMS presents some limitations: the hematocrit influencing accuracy and inconsistencies regarding the means of spotting samples and adding internal standard on paper. Thus, we provide an overview of analytical methodologies with forensic applications focusing on drugs of abuse and discussing the main particularities, limitations and achievements.

Drug analysis: Comparison between dried plasma spots and liquid plasma samples of trauma patients from Cameroon—A feasibility study

“…12,13 Dried samples are also suitable for analysis of drugs of abuse. 7,14,15 Several devices are available to collect and ship dried matrix spots; some of them are designed to collect defined sample volumes. These devices might be too expensive for use in resource-limited settings.…”

“…Dried blood or plasma spots have been used in epidemiological studies in LMICs, for example, in studies of infectious diseases 6,10,11 and in therapeutic drug monitoring 12,13 . Dried samples are also suitable for analysis of drugs of abuse 7,14,15 …”