2013
DOI: 10.1371/journal.pone.0060569
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Dried Plum’s Unique Capacity to Reverse Bone Loss and Alter Bone Metabolism in Postmenopausal Osteoporosis Model

Abstract: Interest in dried plum has increased over the past decade due to its promise in restoring bone and preventing bone loss in animal models of osteoporosis. This study compared the effects of dried plum on bone to other dried fruits and further explored the potential mechanisms of action through which dried plum may exert its osteoprotective effects. Adult osteopenic ovariectomized (OVX) C57BL/6 mice were fed either a control diet or a diet supplemented with 25% (w/w) dried plum, apple, apricot, grape or mango fo… Show more

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Cited by 72 publications
(54 citation statements)
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“…However, Hooshmand and Arjmandi (2009) suggested that even though dried plum polyphenols have some bone modulating properties, the synergistic effect of these polyphenols, together with potassium and vitamin K, is required to produce potent effects on bone mass and microarchitecture and to reverse ovariectomyinduced bone loss in mature animals. Regardless, compared with other dried fruits (apple, apricot, grape and mango), only the dried plum exhibited an anabolic effect on trabecular bone in the vertebra and prevented bone loss (Rendina et al, 2013).…”
Section: Discussionmentioning
confidence: 87%
See 1 more Smart Citation
“…However, Hooshmand and Arjmandi (2009) suggested that even though dried plum polyphenols have some bone modulating properties, the synergistic effect of these polyphenols, together with potassium and vitamin K, is required to produce potent effects on bone mass and microarchitecture and to reverse ovariectomyinduced bone loss in mature animals. Regardless, compared with other dried fruits (apple, apricot, grape and mango), only the dried plum exhibited an anabolic effect on trabecular bone in the vertebra and prevented bone loss (Rendina et al, 2013).…”
Section: Discussionmentioning
confidence: 87%
“…Dietary supplementation of dried plum (25%) in adult mice for 4 or 12 weeks Improvement in bone mass and structure (Rendina et al, 2013) USA Dried plum (P.…”
Section: Domestica)mentioning
confidence: 99%
“…Walau bagaimanapun, tindakan radikal bebas ini dapat dihalang oleh molekul antioksidan dalam badan seperti enzim superoksida dismutase (SOD) dan glutation peroksida (GPX) (Behfar et al 2008;Sen et al 2010). Osteoporosis merendahkan SOD dan GPX sebagai mana yang dapat dilihat pada haiwan terovariektomi (Abujazia et al 2012;Muthusami et al 2005;Rendina et al 2013) dan juga wanita-wanita yang mengalami osteoporosis pascamenopaus (Maggio et al 2003;Oveisi et al 2011;Sánchez-Rodríguez et al 2007).…”
Section: Pengenalanunclassified
“…Kajian terdahulu menunjukkan terdapat beberapa percanggahan dalam keputusan kajian mengenai kesan polifenol terhadap osteokalsin. Pemberian plum kering kepada tikus terovariektomi tidak menunjukkan sebarang perubahan yang signifikan pada kedua-dua ekspresi gen serta aras serum osteokalsin (Franklin et al 2006;Rendina et al 2013). Akan tetapi, kajian menggunakan beri biru pula meningkatkan kedua-duanya .…”
Section: Diet Dan Rawatanunclassified
“…The human diet may contain the phytochemicals possessing antioxidant and anti-inflammatory properties, and antioxidant nutrients may enhance bone formation and reduce the production of free radicals that contribute to bone resorption (8,9). Furthermore, the bone-protective effects of estrogen may involve the suppression of inflammatory cytokines such as interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) (10).…”
Section: Introductionmentioning
confidence: 99%