Drift-Free pH Detection With Silicon Nanowire Field-Effect Transistors

Kwon, Daewoong; Lee, Jung Han; Kim, Sihyun; Lee, Ryoongbin; Mo, Huaping; Park, Jisun; Kim, Dae Hwan; Park, Byung‐Gook

doi:10.1109/led.2016.2542846

Cited by 11 publications

(5 citation statements)

References 18 publications

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“…In recent years, field-effect transistor (FET) biosensors have been studied by many researchers [ 1 , 2 , 3 , 4 , 5 ]. However, metal oxide semiconductor field-effect transistors (MOSFETs) cannot break through the 60 mV/dec limit due to the conduction mechanism of thermionic emission.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity Analysis of Biosensors Based on a Dielectric-Modulated L-Shaped Gate Field-Effect Transistor

et al. 2020

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Label-free biomolecular sensors have been widely studied due to their simple operation. L-shaped tunneling field-effect transistors (LTFETs) are used in biosensors due to their low subthreshold swing, off-state current, and power consumption. In a dielectric-modulated LTFET (DM-LTFET), a cavity is trenched under the gate electrode in the vertical direction and filled with biomolecules to realize the function of the sensor. A 2D simulator was utilized to study the sensitivity of a DM-LTFET sensor. The simulation results show that the current sensitivity of the proposed structure could be as high as 2321, the threshold voltage sensitivity could reach 0.4, and the subthreshold swing sensitivity could reach 0.7. This shows that the DM-LTFET sensor is suitable for a high-sensitivity, low-power-consumption sensor field.

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Section: Introductionmentioning

confidence: 99%

Sensitivity Analysis of Biosensors Based on a Dielectric-Modulated L-Shaped Gate Field-Effect Transistor

et al. 2020

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“…Especially for human being, deviant pH will result in series of serious clinical symptoms, i. e., physical fatigue, memory loss, inattention, and even gout, hypertension, cancer, hyperlipidemia . Great efforts have been made during the past few decades to develop pH detection methods in the environment with excellent selectivity and sensitivity, for example, colorimetric UV‐vis spectroscopy, fluorescence spectroscopy, electrochemical methods, nuclear magnetic resonance, luminescence and field‐effect methods Although the previous methods could monitor pH with satisfied results, there is still a challenge for us to develop some more efficient sensing systems for in‐site pH detection conveniently and quickly.…”

Section: Introductionmentioning

confidence: 99%

A Dual‐Mode Colorimetric/Fluorescent Sensor Comprising Rhodamine B and Piperazine: Response to Acidic pH Values and Investigation of Recognition Mechanism

Luo

Yang

et al. 2020

ChemistrySelect

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A dual‐mode “turn‐on” fluorescent‐colorimetric sensor, 1‐methyl piperazine rhodamine amide (MPRA), has been identified and developed for acidic pH detection in practice. After its structure and photophysical property were characterized and investigated in detail, it was noted to find that nonfluorescent and colorless MPRA would present rose Bengal color and emit strong saffron yellow fluorescence simultaneously with pH decreasing from 7.2 to 1.8 in PBS/acetonitrile (1 : 1, v/v). Under the optimized conditions, MPRA expressed an excellent partitioned and dual‐mode response to pH, i. e., ranging from 1.8 to 3.6 and 3.6 to 7.2 for fluorescent analysis, and 1.8 to 4.0 and 4.0 to 7.2 for colorimetric one with the acidity constant (Ka) of 1.75 obtained from Henderson‐Hasselbach equation. Importantly, the sensing was real‐time and reversible, which was successfully applied for pH detection in real fruit aqueous samples with R.S.D. less than 5.0%. The selective recognition mechanism for MPRA to H+ was confirmed to be the ring‐opened amide form mechanism by 1H NMR and theoretical calculation. MPRA will be a potential dual‐mode sensor for on‐site monitoring pH in acidic environments.

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“…These issues have a direct impact upon the detection limits and the sensor’s reliability. To address these challenges, a large amount of work has been carried out to improve their performance [ 14 , 15 , 16 ], however, most of these improvements lead to either expensive or challenging fabrication processes that, on the majority, may not be suitable for POC diagnostic tools.…”

Section: Introductionmentioning

confidence: 99%

A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform

Zeimpekis

Papadimitriou

et al. 2017

Sensors

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We present a complete biosensing system that comprises a Thin Film Transistor (TFT)-based nanoribbon biosensor and a low noise, high-performance bioinstrumentation platform, capable of detecting sub-30 mpH unit changes, validated by an enzymatic biochemical reaction. The nanoribbon biosensor was fabricated top-down with an ultra-thin (15 nm) polysilicon semiconducting channel that offers excellent sensitivity to surface potential changes. The sensor is coupled to an integrated circuit (IC), which combines dual switched-capacitor integrators with high precision analog-to-digital converters (ADCs). Throughout this work, we employed both conventional pH buffer measurements as well as urea-urease enzymatic reactions for benchmarking the overall performance of the system. The measured results from the urea-urease reaction demonstrate that the system can detect urea in concentrations as low as 25 μM, which translates to a change of 27 mpH, according to our initial pH characterisation measurements. The attained accuracy and resolution of our system as well as its low-cost manufacturability, high processing speed and portability make it a competitive solution for applications requiring rapid and accurate results at remote locations; a necessity for Point-of-Care (POC) diagnostic platforms.

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Drift-Free pH Detection With Silicon Nanowire Field-Effect Transistors

Cited by 11 publications

References 18 publications

Sensitivity Analysis of Biosensors Based on a Dielectric-Modulated L-Shaped Gate Field-Effect Transistor

Sensitivity Analysis of Biosensors Based on a Dielectric-Modulated L-Shaped Gate Field-Effect Transistor

A Dual‐Mode Colorimetric/Fluorescent Sensor Comprising Rhodamine B and Piperazine: Response to Acidic pH Values and Investigation of Recognition Mechanism

A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform

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