Drinking alcohol in moderation is associated with lower rate of all-cause mortality in individuals with higher rather than lower educational level: findings from the MORGAM project

Castelnuovo, Augusto Di; Bonaccio, Marialaura; Costanzo, Simona; McElduff, Patrick; Linneberg, Allan; Salomaa, Veikko; Männistö, Satu; Ferrières, Jean; Dallongeville, Jean; Thorand, Barbara; Brenner, Hermann; Veronesi, Giovanni; Tamošiūnas, Abdonas; Grimsgaard, Sameline; Drygas, Wojciech; Malyutina, S; Söderberg, Stefan; Nordendahl, Maria; Kee, Frank; Dabboura, Salim; Borchini, Rossana; Westermann, Dirk; Schrage, Benedikt; Zeller, Tanja; Kuulasmaa, Kari; Blankenberg, Stefan; Donati, Maria Benedetta; Iacoviello, Licia; Gaetano, Giovanni de

doi:10.1007/s10654-023-01022-3

Cited by 7 publications

(1 citation statement)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…63 71 74 Nevertheless, all-cause mortality associated with light-to-moderate alcohol drinking has also been shown to be modified by educational level, favouring those with higher levels of education. 75 Further research and a comprehensive approach are essential for better understanding the complexities surrounding alcohol consumption and health implications.…”

Section: Open Accessmentioning

confidence: 99%

Social inequality in prevalence of NCD risk factors: a cross-sectional analysis from the population-based Tromsø Study 2015–2016

Hetland,

Wilsgaard,

Hopstock

et al. 2024

BMJ Open

Self Cite

View full text Add to dashboard Cite

ObjectiveWe aimed to examine associations between educational level, serving as an indicator of socioeconomic position, and prevalence of WHO-established leading behavioural and biological risk factors for non-communicable diseases (NCDs), in middle-aged to older women and men.DesignPopulation-based cross-sectional study.SettingAll inhabitants of the municipality of Tromsø, Norway, aged ≥40 years, were invited to the seventh survey (2015–2016) of the Tromsø Study; an ongoing population-based cohort study.ParticipantsOf the 32 591 invited; 65% attended, and a total of 21 069 women (53%) and men aged 40–99 years were included in our study.Outcome measuresWe assessed associations between educational level and NCD behavioural and biological risk factors: daily smoking, physical inactivity (sedentary in leisure time), insufficient fruit/vegetable intake (<5 units/day), harmful alcohol use (>10 g/day in women, >20 g/day in men), hypertension, obesity, intermediate hyperglycaemia and hypercholesterolaemia. These were expressed as odds ratios (OR) per unit decrease in educational level, with 95% CIs, in women and men.ResultsIn women (results were not significantly different in men), we observed statistically significant associations between lower educational levels and higher odds of daily smoking (OR 1.69; 95% CI 1.60 to 1.78), physical inactivity (OR 1.38; 95% CI 1.31 to 1.46), insufficient fruit/vegetable intake (OR 1.54, 95% CI 1.43 to 1.66), hypertension (OR 1.25; 95% CI 1.20 to 1.30), obesity (OR 1.23; 95% CI 1.18 to 1.29), intermediate hyperglycaemia (OR 1.12; 95% CI 1.06 to 1.19), and hypercholesterolaemia (OR 1.07; 95% CI 1.03 to 1.12), and lower odds of harmful alcohol use (OR 0.75; 95% CI 0.72 to 0.78).ConclusionWe found statistically significant educational gradients in women and men for all WHO-established leading NCD risk factors within a Nordic middle-aged to older general population. The prevalence of all risk factors increased at lower educational levels, except for harmful alcohol use, which increased at higher educational levels.

show abstract

Section: Open Accessmentioning

confidence: 99%

Social inequality in prevalence of NCD risk factors: a cross-sectional analysis from the population-based Tromsø Study 2015–2016

Hetland,

Wilsgaard,

Hopstock

et al. 2024

BMJ Open

Self Cite

View full text Add to dashboard Cite

show abstract

Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors

Ortolá,

Sotos-Prieto,

García-Esquinas

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceAlcohol consumption is a leading cause of morbidity and mortality that may be more important in older adults with socioeconomic or health-related risk factors.ObjectiveTo examine the association of alcohol consumption patterns with 12-year mortality and its modification by health-related or socioeconomic risk factors.Design, Setting, and ParticipantsThis prospective cohort study used data from the UK Biobank, a population-based cohort. Participants were current drinkers aged 60 years or older. Data were analyzed from September 2023 to May 2024.ExposureAccording to their mean alcohol intake in grams per day, participants’ drinking patterns were classified as occasional: ≤2.86 g/d), low risk (men: &gt;2.86-20.00 g/d; women: &gt;2.86-10.00 g/d), moderate risk (men: &gt;20.00-40.00 g/d; women: &gt;10.00-20.00 g/d) and high risk (men: &gt;40.00 g/d; women: &gt;20.00 g/d).Main Outcomes and MeasuresHealth-related risk factors were assessed with the frailty index, and socioeconomic risk factors were assessed with the Townsend deprivation index. All-cause and cause-specific mortality were obtained from death certificates held by the national registries. Analyses excluded deaths in the first 2 years of follow-up and adjusted for potential confounders, including drinking patterns and preferences.ResultsA total of 135 103 participants (median [IQR] age, 64.0 [62.0-67.0] years; 67 693 [50.1%] women) were included. In the total analytical sample, compared with occasional drinking, high-risk drinking was associated with higher all-cause (hazard ratio [HR], 1.33; 95% CI, 1.24-1.42), cancer (HR, 1.39; 95% CI, 1.26-1.53), and cardiovascular (HR, 1.21; 95% CI, 1.04-1.41) mortality; moderate-risk drinking was associated with higher all-cause (HR, 1.10; 95% CI, 1.03-1.18) and cancer (HR, 1.15; 95% CI, 1.05-1.27) mortality, and low-risk drinking was associated with higher cancer mortality (HR, 1.11; 95% CI, 1.01-1.22). While no associations were found for low- or moderate-risk drinking patterns vs occasional drinking among individuals without socioeconomic or health-related risk factors, low-risk drinking was associated with higher cancer mortality (HR, 1.15; 95% CI, 1.01-1.30) and moderate-risk drinking with higher all-cause (HR, 1.10; 95% CI, 1.01-1.19) and cancer (HR, 1.19; 95% CI, 1.05-1.35) mortality among those with health-related risk factors; low-risk and moderate-risk drinking patterns were associated with higher mortality from all causes (low risk: HR, 1.14; 95% CI, 1.01-1.28; moderate risk: HR, 1.17; 95% CI, 1.03-1.32) and cancer (low risk: HR, 1.25; 95% CI, 1.04-1.50; moderate risk: HR, 1.36; 95% CI, 1.13-1.63) among those with socioeconomic risk factors. Wine preference (&gt;80% of alcohol from wine) and drinking with meals showed small protective associations with mortality, especially from cancer, but only in drinkers with socioeconomic or health-related risk factors and was associated with attenuating the excess mortality associated with high-, moderate- and even low-risk drinking.Conclusions and RelevanceIn this cohort study of older drinkers from the UK, even low-risk drinking was associated with higher mortality among older adults with health-related or socioeconomic risk factors. The attenuation of mortality observed for wine preference and drinking only during meals requires further investigation, as it may mostly reflect the effect of healthier lifestyles, slower alcohol absorption, or nonalcoholic components of beverages.

show abstract

Should we remove wine from the Mediterranean diet?: a narrative review

Martínez-González

2024

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

Drinking alcohol in moderation is associated with lower rate of all-cause mortality in individuals with higher rather than lower educational level: findings from the MORGAM project

Cited by 7 publications

References 49 publications

Social inequality in prevalence of NCD risk factors: a cross-sectional analysis from the population-based Tromsø Study 2015–2016

Social inequality in prevalence of NCD risk factors: a cross-sectional analysis from the population-based Tromsø Study 2015–2016

Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors

Should we remove wine from the Mediterranean diet?: a narrative review

Contact Info

Product

Resources

About