Drug Absorption and Exsorption Kinetics in Goldfish

Comparative Chemical and Toxicological Evaluation of Residual Ethylene Oxide in Sterilized Plastics

“…A similar degree of enhancement of 4-aminoantipyrine uptake in goldfish was observed in the presence of 0.01 polysorbate 80 (10). These findings illustrate the considerable lot-to-lot variations frequently observed in studies utilizing goldfish (8). These findings illustrate the considerable lot-to-lot variations frequently observed in studies utilizing goldfish (8).…”

“…8 Marlex 6009. constant of ethylene oxide for polyethylene reported by Yasuda (17). after sterilization varies from 50 to 94%, which brings these particular polymers below the toxicity level by the test systems used in this report.…”

Amorphous cyclosporin A nanoparticles for enhanced dermal bioavailability

“…Sometimes addition of surfactant and formation of micelles can even reduce the release and subsequent absorption, e.g. shown in the well known gold fish test by Levy and Miller (1965). Preferable is the increase in saturation solubility by physical means such as changing the crystalline state, preferably making materials amorphous, or by reducing the drug crystal size to the nanodimension, i.e.…”

Perspectives on the history and scientific contributions of Gerhard Levy

“…2 He invited the top students in this course (including WJJ) to work in his laboratory as undergraduate research participants [71]. One such student, Karen E. Miller, received an undergraduate research award from the American Pharmaceutical Association for her studies of drug absorption kinetics in goldfish [72]. Gary and Howard Schaeffer promoted student participation in research in an article published in the American Journal of Pharmaceutical Education in 1962 [73].…”