Drug analysis by capillary electrophoretic methods

Jinno, Kiyokatsu; Sawada, Hirokazu; Han, Y.

doi:10.1002/(sici)1099-0801(199805/06)12:3<126::aid-bmc777>3.0.co;2-h

Cited by 21 publications

(13 citation statements)

References 16 publications

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“…Combination of SPME preconcentration with MEKC separation was also examined 26,27 for the analysis of benzodiazepines. The SPME fiber was exposed to a 10 mL 13 ANALYTICAL SCIENCES JANUARY 2002, VOL.…”

Section: Conventional Spme Coupled With Lc and Mekcmentioning

confidence: 99%

Miniaturized Sample Preparation and Separation Methods for Environmental and Drug Analyses

et al. 2002

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Miniaturized extraction and separation media have been successfully developed from precisely controlled technologies. In this article, recent developments in these high performance analytical methods, such as miniaturized sample preparation methods and the coupling of these techniques with microscale separation systems, have been reviewed, along with some applications to environmental and biological analysis. The advantage of the miniaturization is not only for the environmental compatibility but also for the developments of the high performance analytical systems. Down-sizing also makes it possible to investigate and introduce various compounds and materials as novel media (such as tailor-made materials and devices) in separation science. As a typical example of the novel miniaturized sample preparation system, the applications of fibrous materials for microcolumn liquid-phase separation methods are described.

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Section: Conventional Spme Coupled With Lc and Mekcmentioning

confidence: 99%

Miniaturized Sample Preparation and Separation Methods for Environmental and Drug Analyses

et al. 2002

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“…By immersing the SPME fiber in the sample solution, the analytes are extracted to the polymer coatings on the optical fiber, and then the fiber is transferred into the GC injection port where the analyte molecules are desorbed by heating. In contrast to the above successful applications, the coupling of the SPME method with LC [5,6,7,8,9,11] and with electro-driven separations [12,13,14] for the determination of non-volatile or thermally liable compounds is relatively limited because of the difficult interfacing and the time-consuming operation.…”

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confidence: 99%

Miniaturized solid-phase extraction as a sample preparation technique for the determination of phthalates in water

et al. 2002

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Miniaturized solid-phase extraction (SPE) has been developed and successfully employed for the determination of organic species in water samples by liquid chromatography (LC). The method is based on the concept of a microscale extraction technique using a fused-silica capillary column for gas chromatography (GC), so-called in-tube solid-phase microextraction (SPME). The extraction conditions, such as the extraction time and flow-rate for the extraction and desorption process, were investigated as well as the effect of the internal structure of the extraction capillary on the efficiency. By inserting a stainless steel wire into the extraction capillary to reduce the internal volume of the capillary with the same surface area of the coating, an improved extraction and pre-concentration effects were obtained. Further pre-concentration was accomplished by the extraction device with a novel fiber-in-tube configuration. The direct coupling of the extraction method with a LC system has made it possible to determine low levels of phthalates in water samples without high consumption of organic solvents. The system developed must have potential applications for the analysis of environmental and biological samples in aqueous sample matrices.

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“…Capillary electrophoresis (CE) is one of the most powerful methods for the separation of biological and pharmaceutical compounds. Therefore, one can conclude that the on-line coupling of SPME to CE is a valuable tool for the analysis of trace amounts of compounds in a complex sample matrix, because the on-line coupling is expected to have more efficient preconcentration ability and requires easier operation than conventional off-line SPME-CE applications, as previously reported [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 73%

Sample preparation with fiber-in-tube solid-phase microextraction for capillary electrophoretic separation of tricyclic antidepressant drugs in human urine

et al. 2001

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Solid-phase microextraction (SPME) is a solvent-free sample preparation technique using a thin coating attached to the surface of a fused silica-fiber as the extraction medium, which has been successfully applied to the analysis of a wide variety of compounds by coupling to gas chromatography (GC). In recent years, in-tube SPME using GC capillary column as the extraction medium has also been developed and coupled with liquid chromatography (LC) for the preconcentration of nonvolatile compounds. In this study, an on-line interface between the fiber-in-tube SPME and capillary electrophoresis (CE) has been developed, and the preconcentration and separation of four tricyclic antidepressant (TCA) drugs, amitriptyline, imipramine, nortriptyline, and desipramine, were performed with the hyphenated system. Under the optimized condition, a better extraction performance than conventional in-tube SPME was obtained, even the length of the extraction medium was much shorter. The results clearly indicated that the fiber was working effectively as an extraction medium. For the separation of these four TCAs, capillary electrophoretic separation with beta-cyclodextrin as the buffer additive has been employed and the application of the developed system to the analysis of complex sample mixtures in a biological matrix is also demonstrated.

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Drug analysis by capillary electrophoretic methods

Cited by 21 publications

References 16 publications

Miniaturized Sample Preparation and Separation Methods for Environmental and Drug Analyses

Miniaturized Sample Preparation and Separation Methods for Environmental and Drug Analyses

Miniaturized solid-phase extraction as a sample preparation technique for the determination of phthalates in water

Sample preparation with fiber-in-tube solid-phase microextraction for capillary electrophoretic separation of tricyclic antidepressant drugs in human urine

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