Drug delivery

Nayak, Amit Kumar; Syed, Anees A.; Beg, Sarwar; Ara, Tahseen Jahan; Hasnain, M. Saquib

doi:10.1016/b978-0-12-813741-3.00012-1

Cited by 30 publications

(9 citation statements)

References 82 publications

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“…The equation ( 1) is used to compute the excess (or mixing) enthalpy value of stoichiometric m: n mixes of the virtual liquid using these data. [82] ΔH ex = H API∕Cof − x m H API − x n H Cof (1) where H API , H Cof and H API∕Cof represent the enthalpies in the pure reference state of the API and the pure reference of the coformer and in the m:n mixture, respectively; x m and x n are the mole fractions x m = m/(m + n) and is shown. These small charges will be then used by COSMOthermX to calculate the energy coming from the interactions of the API with the coformer, the API with the API and also the coformer with the coformer.…”

Section: Computational Studiesmentioning

confidence: 99%

“…Most of the medications are taken orally in the form of pills, capsules, liquids, suspensions. [1,2] In a contrast to, for instance, intravenous injection, oral intake of medications is often seen as the most preferable and more patient-convenient option. However, the limited water solubility of orally taken pharmaceuticals continues to pose a challenge for their efficacy.…”

Section: Introductionmentioning

confidence: 99%

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Advances in Carbamazepine Cocrystals: A Review

Kalantri,

Yadav

2024

Cryst. Res. Technol.

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Carbamazepine (CBZ), a widely used antiepileptic drug, is known for its therapeutic efficacy but exhibits suboptimal physicochemical characteristics, including limited bioavailability, low solubility, and poor dissolution rates. In recent years, cocrystallization has emerged as a promising approach to improve these properties and enhance the overall performance of CBZ. This review paper presents a comprehensive exploration of the advances in CBZ cocrystals, focusing on their role in enhancing bioavailability, solubility/dissolution rates, morphology, and stability compared to raw CBZ. It delves into the in‐depth examination of computational techniques, such as molecular modelling and crystal structure prediction, that play a pivotal role in the rational design and prediction of CBZ cocrystals, thereby expediting the development process. Additionally, the morphological attributes of CBZ cocrystals are discussed, shedding light on how the unique crystal structures affect their physical properties. Stability is another critical aspect addressed in this review, encompassing thermal, physical, and chemical stability. The thermal behavior of CBZ cocrystals is analyzed through differential scanning calorimetry (DSC), and their crystal structures are characterized by techniques such as X‐ray diffraction (XRD) and Fourier‐transform infrared spectroscopy (FTIR). These analyses reveal the stability and structural changes of CBZ cocrystals under various conditions, providing valuable insights for formulation and storage. In summary, this comprehensive review paper amalgamates the latest advancements in CBZ cocrystals, demonstrating their capacity to significantly improve bioavailability, solubility, dissolution rates, and stability.

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Section: Computational Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advances in Carbamazepine Cocrystals: A Review

Kalantri,

Yadav

2024

Cryst. Res. Technol.

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“…While according to Mane and Muro (2012) the biodistribution and cellular uptake of polystyrene nanoparticles coated with anti-ICAM-1 antibodies was evaluated. According to Nayak et al (2018), the current status of drug delivery technologies was explored and highlighted. The study thereby asserted examples of newer devices with tremendously improved therapeutic potential including oral controlled release systems, liposomes, fast dispersing dosage forms, taste-masking systems, aerosols, transdermal patches, and site-specific delivery systems.…”

Section: Need Of Ligand Based Colon Targeted Drug Deliverymentioning

confidence: 99%

Significance of Ligand-Anchored Polymers for Drug Targeting in the Treatment of Colonic Disorders

2020

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Treatment of a variety of bowel diseases like Crohn's disease, ulcerative colitis, colonic cancers, colonic pathologies, and systemic delivery of drugs at the target sites can be done with the help of targeted drug delivery technique. Conventional colon specific drug delivery systems lack specificity and release significant amount of drug prior reaching the target site. Hence, efficient drug delivery system that ensures effective release of the drug at the colon is still a sought after research arena. Ligand anchored therapy is a strong and effective approach to execute drug delivery in selective target cells, for both, diagnostic, as well as therapeutic reasons. Compared to the regular drugs, such ligand anchored therapy provides added benefit of minimum toxicity and few side effects. Discovery of overexpressed receptors on diseased cells, as compared to healthy cells led to the emergence of active drug targeting. Further, drug resistance constitutes one of the major reasons of the failure of chemotherapy and presents a major obstacle for the effective treatment. The reason behind drug resistance is exposure of pathological cells/pathogens to sub-therapeutic levels of drugs due lack of specificity of therapeutics. Active targeting, specifically taken up by the target cells, can warrant exposure of pathological cells/ pathogens to high drug load at the target and sparing non-target cells hence minimal damage to normal cells and least chance of drug resistance. Many ligands like antibodies, aptamers, peptides, folate, and transferrin have been discovered in the past few years. The design of nanocarriers can be incorporated with many different functions which enables functions like imaging and triggered intracellular drug release. The present review article focuses on advances in ligand anchored therapy and its significance on the progress of targeted nanocarriers. It will also establish novel concepts like multitargeting and multi-functional nanocarriers for the treatment of colonic disorders.

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“…They are defined as systems that have the ability to incorporate and protect a drug to improve its selectivity, bioavailability, and efficacy [ 1 ]. The development of drug delivery systems in order to achieve the therapeutic effects of drugs has contributed to the treatment of various diseases and has led to scientific progress in the field of drug therapy [ 2 , 3 ]. The use of drug carriers is considered a way to overcome problems such as low bioavailability, poor solubility in water, and biological degradation of most medicinal substances [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

Milutinov,

Krstonošić,

Ćirin

et al. 2023

Polymers

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Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and industrial interest due to their ability to incorporate and protect active substances, thus improving their selectivity, bioavailability, and efficacy. Emulgels are emerging carrier systems that represent a mixture of emulsion and gel, which are particularly significant for the delivery of hydrophobic substances. However, the proper selection of main constituents determines the stability and efficacy of emulgels. Emulgels are dual-controlled release systems, where the oil phase is utilized as a carrier for hydrophobic substances and it determines the occlusive and sensory properties of the product. The emulsifiers are used to promote emulsification during production and to ensure emulsion stability. The choice of emulsifying agents is based on their capacity to emulsify, their toxicity, and their route of administration. Generally, gelling agents are used to increase the consistency of formulation and improve sensory properties by making these systems thixotropic. The gelling agents also impact the release of active substances from the formulation and stability of the system. Therefore, the aim of this review is to gain new insights into emulgel formulations, including the components selection, methods of preparation, and characterization, which are based on recent advances in research studies.

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Drug delivery

Cited by 30 publications

References 82 publications

Advances in Carbamazepine Cocrystals: A Review

Advances in Carbamazepine Cocrystals: A Review

Significance of Ligand-Anchored Polymers for Drug Targeting in the Treatment of Colonic Disorders

Emulgels: Promising Carrier Systems for Food Ingredients and Drugs

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