Drug Delivery: A Sequentially Triggered Nanosystem for Precise Drug Delivery and Simultaneous Inhibition of Cancer Growth, Migration, and Invasion (Adv. Funct. Mater. 43/2016)

Abstract

A precise drug delivery system for simultaneously inhibiting cancer growth, migration, and invasion is presented by Tianfeng Chen and co‐workers on page 7775. The sequentially triggered nanosystem decorated by HER2 antibody with disulfide linkages provides a valid tactic for the rational design of smart nanosystems for drug delivery and therapy.

Designing Core–Shell Gold and Selenium Nanocomposites for Cancer Radiochemotherapy

“…For instance, Au@Se-R/A NCs (8 μM) and X-ray increase of the sub-G1 peak to 43.6% and combination of X-ray and Au NRs (0.2 μM), Se NCs (8 μM), and Au@Se NCs (8 μM) increases cell apoptosis to 7.0, 18.0, and 28.5% (Figure S6). The results indicate synergistic anticancer action through promotion of cell apoptosis, in which caspase family members play a critical role. ,, Se NPs also show anticancer effects by caspase-mediated apoptosis in different cancer cells. ,, Therefore, the expression levels of caspase family and other related proteins are determined by Western blotting. As shown in Figure S7, exposure of A375 cells to Au@Se-R/A NCs and X-ray activates caspase-3/-8/-9 as well as poly-ADP-ribose polymerase (PARP) cleavage, providing more evidence about that the synergistic effects of the combined treatment arising from the caspase-mediated apoptotic pathway.…”

“…To integrate radiotherapy and chemotherapy, a Au-based nanocomposite (NC), core–shell structured Au@Se NC, is synthesized and evaluated in this work. Se NPs have been studied by some groups including ours and proposed as an efficient anticancer nanoagent and drug carrier. − We have recently reported that conjugation of cancer-targeting units improves the stability and anticancer efficacy of Se NPs, ,, and smart decoration of Se NPs can produce sequentially triggered drug release, precise drug delivery, and simultaneous inhibition of cancer growth, migration, and invasion . Here, we synthesized a Au@Se NC that combines Au nanorods (NRs) and Se NP.…”