Drug Delivery Approaches for the Treatment of Cervical Cancer

Ordikhani, Farideh; Arslan, Mustafa Erdem; Marcelo, Raymundo; Şahin, İlyas; Grigsby, Perry W.; Azab, Abdel Kareem

doi:10.3390/pharmaceutics8030023

Cited by 75 publications

(41 citation statements)

References 114 publications

(130 reference statements)

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“…In this context, a lot of research has been done to synthesize new classes of materials, including those at nanoscale, and test their anticancer properties and/or their application in cancer early detection approaches [3,4]. Silver nanoparticles (AgNPs) are widely applied in cancer research due to their potent in vitro antitumor effects on cancer cell lines including breast and cervical cancer models [5,6]. e cytotoxic response that a nanoparticle could trigger in cells depends not only on its physical and chemical characteristics [3], but also, since different cell lines do not respond identically to stimuli with the same nanoparticles, on the cell type [7].…”

Section: Introductionmentioning

confidence: 99%

Biological Effect of Organically CoatedGrias neuberthiiandPersea americanaSilver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines

Salazar

López

Grijalva

et al. 2018

Journal of Nanotechnology

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The aim of this study was to assess the biological effect of organically coated Grias neuberthii (piton) fruit and Persea americana (avocado) leaves nanoparticles (NPs) on cervical cancer (HeLa) and breast adenocarcinoma (MCF-7) cells with an emphasis on gene expression (p53 transcription factor and glutathione-S-transferase GST) and cell viability. UV-Vis spectroscopy analysis showed that synthesized AgNPs remained partially stable under cell culture conditions. HeLa cells remained viable when exposed to piton and avocado AgNPs. A statistically significant, dose-dependent cytotoxic response to both AgNPs was found on the breast cancer (MCF-7) cell line at concentrations above 50 µM. While expression levels of transcription factor p53 showed downregulation in treated MCF-7 and HeLa cells, GST expression was not affected in both cell lines treated. Cell viability assays along with gene expression levels in treated MCF-7 cells support a cancer cell population undergoing cell cycle arrest. The selective toxicity of biosynthesized piton/avocado AgNPs on MCF-7 cells might be of value for novel therapeutics.

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Section: Introductionmentioning

confidence: 99%

Biological Effect of Organically CoatedGrias neuberthiiandPersea americanaSilver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines

Salazar

López

Grijalva

et al. 2018

Journal of Nanotechnology

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“…In the current experiment, the antiproliferative activity of AuNPs nanoparticles to human cervical cancer cells was investigated. Nanoparticles is considered an important drug delivery methods for cervical Cancer treatment [24]. Gold nanoparticles reported to have an anti-cervical cancer properties [19].…”

Section: Discussionmentioning

confidence: 99%

Gold Nanoparticles Targeting Human Cervical Cancer Cells

Merkadh¹,

Hameed²

2019

SIJOG

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The most disturbing gynecologic malignancies are cervical cancer particularly in the developing world with the same high incidence in Iraqi women. Cervical carcinoma has a high rate of mortality. The high death rate is associated with presence of human papillomavirus (HPV) infection. Cervical carcinoma is hard to treat, and conventional therapies are very aggressive which lead for the need for new approaches of therapy. Nanoparticles is a promising treatment modality to produce non-toxic and efficient cancer therapy. Gold nanoparticles (AuNPs) accumulate in cancer cells selectively. The current work was aimed to study cytotoxicity and cell death induced by AuNPs on cervical carcinoma cells. Methods: Cytotoxicity of AuNPs was assessed by MTT viability assay and analysed using multiple comparison ANOVA tests. Results: AuNPs nanoparticles from 12.5 up to 50 µg/mL for 72 hours showed concentration-dependent killing activity. Conclusion: Gold nanoparticles have anti-cervical carcinoma cells activity by cell death induction.

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“…Their structure allows the attachment and presentation of antigen molecules at their periphery, producing them as predominantly multifunctional. Drugs can be loaded into cavities in their cores by chemical linkages, hydrophobic interactions, hydrogen bonds, or conjugation to the polymer scaffold [99]. Polyacrylate star polymer conjugated to HPV E7 protein has been used to overcome the poor immunogenicity of peptide-based vaccines against cervical cancer.…”

Section: Systemic Versus Localized Drug Delivery Systemsmentioning

confidence: 99%

Possible role of nanocarriers in drug delivery against cervical cancer

Gupta

2017

Nano Reviews & Experiments

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Introduction: Cervical cancer is the second most common cancer and the largest cancer killer among women in most developing countries including India. Although, various drugs have been developed for cervical cancer, treatment with these drugs often results in a number of undesirable side effects, toxicity and multidrug resistance (MDR). Also, the outcomes for cervical cancer patients remain poor after surgery and chemo radiation. Methods: A literature search (for drugs and delivery systems against cervical cancer) was performed on PubMed and through Google. The present review discuss about various methods including its current conventional treatment with special reference to recent advances in delivery systems encapsulating various anticancer drugs and natural plant products for targeting towards cervical cancer. The role of photothermal therapy, gene therapy and radiation therapy against cervical cancer is also discussed. Results: Systemic/targeted drug delivery systems including liposomes, nanoparticles, hydrogels, dendrimers etc. and localized drug delivery systems like cervical patches, films, rings etc. are safer than the conventional chemotherapy which has further been proved by the several drug delivery systems undergoing clinical trials. Conclusion: Novel approaches for the aggressive treatment of cervical cancer will optimistically result in decreased side effects as well as toxicity, frequency of administration of existing drugs, to overcome MDR and to increase the survival rates.

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Drug Delivery Approaches for the Treatment of Cervical Cancer

Cited by 75 publications

References 114 publications

Biological Effect of Organically CoatedGrias neuberthiiandPersea americanaSilver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines

Biological Effect of Organically CoatedGrias neuberthiiandPersea americanaSilver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines

Gold Nanoparticles Targeting Human Cervical Cancer Cells

Possible role of nanocarriers in drug delivery against cervical cancer

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