Drug delivery studies on electrostatically charged dry powder inhaler aerosols using a glass bead lung model

Saini, D.; Yurteri, Caner Ü.; Grable, N.; Sims, Robert; Mazumder, Malay K.

doi:10.1109/ias.2002.1042789

Cited by 10 publications

(9 citation statements)

References 3 publications

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“…[Balachandran 1997]. A glass bead lung model [Saini 2002] has been developed ( Figure 15) to study the site-specific deposition as function of size and charge of the drug particles. The experimental setup includes the surrogate lung, an anatomical throat section, spinning disc aerosol generators, flow control system, and an ESPART analyzer.…”

Section: Effect Of Particle Size and Charge On The Lung Deposition Of Imentioning

confidence: 99%

Twenty-first century research needs in electrostatic processes applied to industry and medicine

Mazumder

Sims

Biris

et al. 2006

Chemical Engineering Science

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109

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From the early century Nobel Prize winning (1923) experiments with charged oil droplets, resulting in the discovery of the elementary electronic charge by Robert Millikan, to the early 215t century Nobel Prize (2002) awarded to John Feim for his invention of electrospray ionization mass spectroscopy and its applications to proteomics, electrostatic processes have been successfully applied to many areas of industry and medicine. Generation, transport, deposition, separation, analysis, and control of charged particles involved in the four states of matter: solid, liquid, gas, and plasma are of interest in many industrial and biomedical processes. In this paper, we briefly discuss some of the applications and research needs involving charged particles in industrial and medical applications including: (1) Generation and deposition of unipolarly charged dry powder without the presence of ions or excessive ozone, (2) Control of tribocharging process for consistent and reliable charging, (3) Thin film (< 25 i.m) powder coating and Powder coating on insulative surfaces, (4) Fluidization and dispersion of fine powders, (5) Mitigation of Mars dust, (6) Effect of particle charge on the lung deposition of inhaled medical aerosols, (7) Nanoparticle deposition, and (8) Plasma/Corona discharge https://ntrs.nasa.gov/search.jsp?R=20120003223 2018-05-10T11:56:16+00:00Z

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Section: Effect Of Particle Size and Charge On The Lung Deposition Of Imentioning

confidence: 99%

Twenty-first century research needs in electrostatic processes applied to industry and medicine

Mazumder

Sims

Biris

et al. 2006

Chemical Engineering Science

Self Cite

109

View full text Add to dashboard Cite

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“…Most of the mouth-throat deposition data in the literature are for human adults and uncharged particles (Foord et al 1978;Chan and Lippmann 1980;Emmett et al 1982;Brancatisano et al 1983;Stahlhofen et al 1983;Bowes and Swift 1989;Borgström 1999;Cass et al 1999;Finlay 2001, 2004;Grgic et al 2004;Zhou et al 2011). A number of authors have examined deposition of charged aerosols in adults (Melandri et al 1983;Hashish 1992;Hashish et al 1994;Balachandran et al 1997;Bailey et al 1998;Saini et al 2002Saini et al , 2004Ali et al 2008Ali et al , 2009Majid et al 2012;Azhdarzadeh et al 2014). However, there is comparatively little data on oral airway deposition for children (Becquemin et al 1991;Mitchell and Nagel 1997;Bennett and Zeman 2004;Bickmann et al 2008;Schueepp et al 2009;Below et al 2013;Golshahi et al 2013), and all previous pediatric work is for uncharged aerosols.…”

Section: Introductionmentioning

confidence: 99%

Effect of Induced Charge on Deposition of Uniformly Charged Particles in a Pediatric Oral-Extrathoracic Airway

Azhdarzadeh

Olfert

Vehring

et al. 2014

Aerosol Science and Technology

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An in vitro study was conducted in the Alberta idealized child mouth-throat, which mimics average deposition in a set of nine 6-14-year-old subjects, to examine the enhancement of deposition of monodisperse uniformly charged particles as a result of induced electrostatic forces. A purpose-based atomizer was designed and built for generating monodisperse, uniformly charged particles. The atomizer generates droplets by jet break up under the action of capillary waves and charges them via electrostatic induction. The experiments cover different particle aerodynamic diameters (d a = 3.6, 4.4, and 5.9 µm), at two flow rates (Q = 10 and 20 L/min), over a wide range of elementary charges per particle (0-10,000 e). The results show substantial increases in particle deposition in the present idealized pediatric mouth throat compared to neutral aerosols. Two empirical equations, as a function of Reynolds number, Stokes number, and induced charge number are introduced for the prediction of mouth-throat deposition in children, based on two different characteristic diameters of the airway.

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“…Gebhart and Heyder (1985) used a granular bed composed of glass beads to simulate particle deposition in the human respiratory tract. Saini et al (2002) developed a physical lung model using glass beads to study the lung deposition of charged aerosol particles.…”

Section: Introductionmentioning

confidence: 99%

A Granular Bed for Use in a Nanoparticle Respiratory Deposition Sampler

Park

Mudunkotuwa

Mines

et al. 2015

Aerosol Science and Technology

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A granular bed was designed to collect nanoparticles as an alternative to nylon mesh screens for use in a nanoparticle respiratory deposition (NRD) sampler. The granular bed consisted of five layers in series: a coarse mesh, a large-bead layer, a small-bead layer, a second large-bead layer, and a second coarse mesh. The bed was designed to primarily collect particles in the small-bead layer, with the coarse mesh and large-bead layers designed to hold the collection layer in position. The collection efficiency of the granular bed was measured for varying depths of the small-bead layer and for test particles with different shape (cuboid, salt particles; and fractal, and stainless steel and welding particles). Experimental measurements of collection efficiency were compared to estimates of efficiency from theory and to the nanoparticulate matter (NPM) criterion, which was established to reflect the total deposition in the human respiratory system for particles smaller than 300 nm. The shape of the collection efficiency curve for the granular bed was similar to the NPM criterion in these experiments. The collection efficiency increased with increasing depth of the small-bead layer: the particle size associated with 50% collection efficiency, d 50 , for salt particles was 25 nm for a depth of 2.2 mm, 35 nm for 3.2 mm, and 45 nm for 4.3 mm. The best-fit to the NPM criterion was found for the bed with a small-bead layer of 3.2 mm. Compared to cubic salt particles, the collection efficiency was higher for fractal-shaped particles larger than 50 nm, presumably due to increased interception.

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Drug delivery studies on electrostatically charged dry powder inhaler aerosols using a glass bead lung model

Cited by 10 publications

References 3 publications

Twenty-first century research needs in electrostatic processes applied to industry and medicine

Twenty-first century research needs in electrostatic processes applied to industry and medicine

Effect of Induced Charge on Deposition of Uniformly Charged Particles in a Pediatric Oral-Extrathoracic Airway

A Granular Bed for Use in a Nanoparticle Respiratory Deposition Sampler

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