Drug delivery systems based on CD44-targeted glycosaminoglycans for cancer therapy

Li, Min; Sun, Jiao; Zhang, Wenjun; Zhao, Yinan; Zhang, Shufen; Zhang, Shubiao

doi:10.1016/j.carbpol.2020.117103

Cited by 94 publications

(48 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several HA based nanomaterials are used in hyperthermia (an increase in the temperature of the cancer cells at about 42–46°C): NIR-loaded nanoparticles, gold nanoparticles, functionalized graphene, oxide nanoparticles, Prussian Blue nanoparticles, and other particles (related to magnetic hyperthermia treatment). In addition, HA based nanoparticles were used in photodynamic therapy, immunotherapy, and sonodynamic therapy [ 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Applications Of Hyaluronic Acidmentioning

confidence: 99%

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

et al. 2021

View full text Add to dashboard Cite

This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used in skin regeneration, with moisturizing and anti-ageing effects. HA molecular weight influences its penetration into the skin and its biological activity. Considering that, nowadays, hyaluronic acid has a wide use and a multitude of applications (in ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, oncology, nutrition, and cosmetics), the present study describes the main aspects related to its use in cosmetology. The biological effect of HA on the skin level and its potential adverse effects are discussed. Some available cosmetic products containing HA have been identified from the brand portfolio of most known manufacturers and their composition was evaluated. Further, additional biological effects due to the other active ingredients (plant extracts, vitamins, amino acids, peptides, proteins, saccharides, probiotics, etc.) are presented, as well as a description of their possible toxic effects.

show abstract

Section: Applications Of Hyaluronic Acidmentioning

confidence: 99%

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In cases where the upregulation of the HAS2 expression was prevented, the DNA damage increased and the survival rate of the irradiated cells decreased. Since HA provides support for cancer cells, the bond between CD44 and HA comprises one of the subjects of ongoing research in the field of anticancer therapy 108 . Leukemic cells also produce high amounts of HA.…”

Section: Proposed Mechanisms Of the Ha Regulation Of Photoagingmentioning

confidence: 99%

Hyaluronan: A key player or just a bystander in skin photoaging?

Šínová

Pavlík

Ondrej

et al. 2021

Experimental Dermatology

View full text Add to dashboard Cite

Photoaged skin exhibits signs of inflammation, DNA damage and changes in morphology that are visible at the macroscopic and microscopic levels. Photoaging also affects the extracellular matrix (ECM) including hyaluronan (HA), the main polysaccharide component thereof. HA is a structurally simple but biologically complex molecule that serves as a water‐retaining component and provides both a scaffold for a number of the proteins of the ECM and the ligand for cellular receptors. The study provides an overview of the literature concerning the changes in HA amount, size and metabolism, and the potential role of HA in photoaging. We also suggest novel HA contributions to photoaging based on our knowledge of the role of HA in other pathological processes, including the senescence and inflammation‐triggered ECM reorganization. Moreover, we discuss potential direct or indirect intervention to mitigate photoaging that targets the hyaluronan metabolism, as well as supplementation.

show abstract

“…Osteosarcoma is a primary bone cancer characterised by cancer cells that produce calcified osteoid extracellular matrix and inducing lung metastases with a high frequency [4]. Despite recent advances in treating osteosarcoma with a combination of chemotherapy and surgery, the 5-year survival rate remains low, and the prognosis for patients is poor [5]. The cellular and molecular mechanisms underlying the progression of osteosarcoma, including the rate of cancer cell proliferation, the formation of metastatic lesions and the development of drug resistance, remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S

Ji¹,

Gan

Cao

et al. 2022

J Orthop Surg Res

View full text Add to dashboard Cite

Background Osteosarcoma (OS) is a malignant bone tumour of mesenchymal origin. These tumours are characterised by rich vascularisation, therefore promoting rapid proliferation and facilitating metastasis. CD44 has been reported to be involved in OS, but its role and molecular mechanisms in the pathogenesis of the disease are not fully determined. Methods In this study, we investigated the antitumor effect of CD44 on the development of OS and further explored the molecular mechanisms. The expression of CD44, cathepsin S and MMP-9 was detected by Western blot (WB) and reverse transcription-polymerase chain reaction (RT-qPCR) in different cell lines (MG63, U2OS OS and hFOB 1.19). To elucidate the role of CD44 in OS, MG63 and U2OS cells were treated with small interference RNA (siRNA) to knock down CD44, and the knockdown efficiency was validated with GFP and RT-qPCR. Furthermore, cell proliferation was assayed using Cell Counting Kit‑8 (CCK-8) and colony formation assays, and cell migration and invasion were assayed by transwell and wound-healing assays. Results We found that CD44 expression in the MG63 and U2OS OS cell lines was markedly increased compared to that of the human osteoblast hFOB 1.19 cell line. Knockdown of CD44 inhibited proliferation, migration and invasion of MG63 and U2OS cells. Cathepsin S expression in the MG63 and U2OS OS cell lines was increased compared to that of the human osteoblast hFOB 1.19 cell line. When CD44 was knocked down, its expression level went down. Conclusion Taken together, our data reinforced the evidence that CD44 knockdown inhibited cell proliferation, migration and invasion of OS cells accompanied by altered expression of cathepsin S. These findings offer new clues for OS development and progression, suggesting CD44 as a potential therapeutic target for OS.

show abstract

Drug delivery systems based on CD44-targeted glycosaminoglycans for cancer therapy

Cited by 94 publications

References 176 publications

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

Hyaluronan: A key player or just a bystander in skin photoaging?

Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S

Contact Info

Product

Resources

About