Drug delivery systems for the treatment of psoriasis: Current status and prospects

Jyothi, S.L.; Krishna, K L; Shirin, V.K. Ameena; Sankar, Renu; Pramod, K.; Gangadharappa, H.V.

doi:10.1016/j.jddst.2021.102364

Cited by 29 publications

(19 citation statements)

References 123 publications

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“…Several skin pathologies imply the use of pharmacological drugs for efficient treatments [155]. Acne [156], psoriasis [157], skin infections [158] are some examples that often require topically applied and skin localized drug delivery. A variety of drugs are intended for topical use against these conditions, such as antibiotics and antifungals, for skin infections; topical corticosteroids, for skin inflammations; topical retinoids, for acne treatment; and local anesthetics, as lidocaine, for dermal anesthesia.…”

Section: Drugsmentioning

confidence: 99%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

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3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the use of 3D printing for the development of pharmaceutical and biomedical products for topical skin applications, covering plain dressing and products for the delivery of active ingredients to the skin. Based on the data acquired, the important growth in the number of publications over the last years confirms its interest. The semisolid extrusion technique has been the most reported one, probably because it allows the use of a broad range of polymers, creating the most diverse therapeutic approaches. 3D printing has been an excellent field for customizing dressings, according to individual needs. Studies discussed here imply the use of metals, nanoparticles, drugs, natural compounds and proteins and peptides for the treatment of wound healing, acne, pain relief, and anti-wrinkle, among others. The confluence of 3D printing and topical applications has undeniable advantages, and we would like to encourage the research groups to explore this field to improve the patient’s life quality, adherence and treatment efficacy.

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Section: Drugsmentioning

confidence: 99%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

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“…The upper respiratory tract infection is occurring followed by streptococcal infection. [15,29,30] Plaques psoriasis/Psoriasis vulgaris (all body but typically on elbows, knees, scalp areas)…”

Section: Guttate Psoriasis (Head and Limbs)mentioning

confidence: 99%

“…The characteristic lesions are dry, sharp and oval in shape which seems as erythematous macules and form plaque. [15] Pustular psoriasis (Palms and soles)…”

Section: Guttate Psoriasis (Head and Limbs)mentioning

confidence: 99%

“…Jyothi et al also described traditional treatments along with nano-carriers and herbals used in psoriasis [15]. The current article gives brief information about conventional treatments for psoriasis and updated comprehensive information on recent advancements in various types of nanotechnology based colloidal drug delivery systems for treatment of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management

et al. 2021

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Psoriasis is a chronic inflammatory autoimmune disorder that moderately affects social and interpersonal relationships. Conventional treatments for psoriasis have certain problems, such as poor drug penetration through the skin, hyper-pigmentation, and a burning sensation on normal and diseased skin. Colloidal drug delivery systems overcome the pitfalls of conventional approaches for psoriasis therapeutics and have improved patient safety parameters, compliance, and superior effectiveness. They also entail reduced toxicity. This comprehensive review’s topics include the pathogenesis of psoriasis, causes and types of psoriasis, conventional treatment alternatives for psoriasis, the need for colloidal drug delivery systems, and recent studies in colloidal drug delivery systems for the treatment of psoriasis. This review briefly describes colloidal drug delivery approaches, such as emulsion systems—i.e., multiple emulsion, microemulsion, and nano-emulsion; vesicular systems—i.e., liposomes, ethosomes, noisomes, and transferosomes; and particulate systems—i.e., solid lipid nanoparticles, solid lipid microparticles, nano-structured lipid carriers, dendrimers, nanocrystals, polymeric nanoparticles, and gold nanoparticles. The review was compiled through an extensive search of the literature through the PubMed, Google Scholar, and ScienceDirect databases. A survey of literature revealed seven formulations based upon emulsion systems, six vesicular drug delivery systems, and fourteen particulate systems reported for antipsoriatic drugs. Based on the literature studies of colloidal approaches for psoriasis management carried out in recent years, it has been concluded that colloidal pharmaceutical formulations could be investigated broadly and have a broad scope for effective management of many skin disorders in the coming decades.

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“…[ 6 ] Topical formulation (ointments, gels, creams, lotions, solutions, suspensions, and shampoos) delivers drugs conveniently to the affected area. [ 7 ] However, only the active agent in the molecular state penetrates the skin. Generally, penetration and biodistribution depends on the barriers such as stratum corneum and the pathophysiological state.…”

Section: Introductionmentioning

confidence: 99%

Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?

Iyer

Jyothi

Agrawal

et al. 2021

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Skin permeation is an integral part of penetration of topical therapeutics. Zero order in addition to Higuchi permeation kinetic is usually preferred in topical drug delivery cargo. Penetration of therapeutic entities through epidermal barrier is a major challenge for scientific fraternity. Furthermore, penetration of therapeutic entities determines the transportation and ultimately therapeutic efficacy of topical dermal dosage forms. Apart from experimentation models, mathematical equations, in silico docking, molecular dynamics (MDs), and artificial neural network (Neural) techniques are being used to assess free energies and prediction of electrostatic attractions in order to predict the permeation phenomena of therapeutic entities. Therefore, in the present review, we have summarized the significance of kinetic equations, in silico docking, MDs, and ANN in assessing and predicting the penetration behavior of topical therapeutics through dermal dosage form. In addition, the role of chitosan biomacromolecule in modulating permeation of topical therapeutics in skin has also been illustrated using computational techniques.

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Drug delivery systems for the treatment of psoriasis: Current status and prospects

Cited by 29 publications

References 123 publications

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management

Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?

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