Drug Delivery Systems: Past, Present, and Future

Abstract

Drug delivery systems are essential components of drugs controlled release. In the last decades, several drug delivery technologies have emerged including capsules, liposomes, microparticles, nanoparticles, and polymers. These components must be biocompatible, biodegradable, and display a desired biodistribution providing a long-term availability of the therapeutic at specific target over time.

Near-Infrared Investigations of Novel Anti-HIV Tenofovir Liposomes

“…However, encapsulating a sufficient amount of the therapeutic agent is considered one of the most desirable properties for liposomes usage (25,26). The therapeutic activity of many liposomal formulations of membrane-permeant drugs will likely depend on the success of efforts to design liposomes having enhanced drug retention characteristics.…”

Recent advances on smart TiO₂ nanotube platforms for sustainable drug delivery applications

“…[1][2][3][4] Approximately 90% of drugs that are used currently on the market are hydrophobic and poorly water-insoluble, and this restricts their pharmacological efficiency and particularly challenges the systemic delivery route. 5,6 Another inherent limitation of the therapies is that various drugs are inactivated or removed by the gastrointestinal system and other body organs including kidney and liver, and only ,1% of administered drug molecules reach the site of interest, where higher dosages of drugs are required to achieve an optimized local concentration.…”

TiO₂ nanotube platforms for smart drug delivery: a review

“…1 The inherent limitations of conventional therapies could be addressed on the basis of developing more efficient and rational drug delivery systems. In this regard, strong interdisciplinary research strategies combining the efforts of material scientists, engineers, medical scientists, biologists, and clinicians have recently demonstrated promising results.…”