Drug Delivery with Designed Peptide Assemblies

Sis, Matthew J.; Webber, Matthew J.

doi:10.1016/j.tips.2019.08.003

Cited by 96 publications

(68 citation statements)

References 134 publications

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“…[ 13 ] Although these peptide assemblies have demonstrated great advantages of nanofibers in medical diagnosis and therapy, there remain practical and system‐specific challenges in the manufacture of peptide materials and complex self‐assembly process. [ 14 ] Since these limitations can be overcome by small‐molecule drugs, recently small molecule‐based nanofibers have drawn attention. However, due to the lack of available fiber‐forming small‐molecule monomers, there are only limited reported cases to date.…”

Section: Introductionmentioning

confidence: 99%

Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Lin

et al. 2020

Adv Funct Materials

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Photodynamic therapy (PDT) has emerged as an attractive alternative in cancer therapy, but its therapeutic effects are limited by the nonselective subcellular localization and poor intratumoral retention of small‐molecule photosensitizes. Here a fiber‐forming nanophotosensitizer (PQC NF) that is composed of mitochondria targeting small molecules of amphiphilicity is reported. Harnessing the specific mitochondria targeting, the light‐activated PQC NFs produce approximately 110‐fold higher amount of reactive oxygen species in cells than free photosensitizers and can dramatically induce mitochondrial disruption to trigger intense apoptosis, showing 20–50 times better in vitro anticancer potency than traditional photosensitizers. As fiber‐shaped nanomaterials, PQC NFs also demonstrated a long‐term retention in tumor sites, solving the challenge of rapid clearance of small‐molecule photosensitizers from tumors. With these advantages, PQC NFs achieve a 100% complete cure rate in both subcutaneous and orthotopic oral cancer models with the administration of only a single dose. This type of single small molecule‐assembled mitochondria targeting nanofibers offers an advantageous strategy to improve the in vivo therapeutic effects of conventional PDT.

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Section: Introductionmentioning

confidence: 99%

Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Lin

et al. 2020

Adv Funct Materials

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“…The peptide sequence was also important, but the first amino acid residue following the alkyl segment plays a vital role in promotingsheet formation and axial elongation into fibers. [61,62] These findings suggest that the morphology, surface chemistry, and potential bioactivity can be engineered more freely by changing the amino acid sequences. Indeed, the morphological of PA-based fibrils could be tuned from short twisted ribbon, to long twisted ribbons and to helical ribbons via engineering three phenylalanine residues.…”

Section: Peptide Amphiphilementioning

confidence: 96%

“…These components can be small-molecule drugs, protein therapeutics, gene therapeutics, or even cells, and the resulting hydrogels have been used in cancer therapy, regenerative medicine, and immune engineering. [62,132,133] Functional components can be introduced into the hydrogels through either physical entrapment or chemical conjugation (Figure 6). Effective cargo loading and its controllable release are key factors to maximize their efficacy.…”

Section: Control Of Cargo Loading and Releasementioning

confidence: 99%

Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy

Cai

Zheng

Xiong

et al. 2020

Adv Healthcare Materials

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Supramolecular peptide hydrogel (SPH) is a class of biomaterials self‐assembled from peptide‐based gelators through non‐covalent interactions. Among many of its biomedical applications, the potential of SPH in cancer therapy has been vastly explored in the past decade, taking advantage of its good biocompatibility, multifunctionality, and injectability. SPHs can exert localized cancer therapy and induce systemic anticancer immunity to prevent tumor recurrence, depending on the design of SPH. This review first gives a brief introduction to SPH and then outlines the major types of peptide‐based gelators that have been developed so far. The methodologies to tune the physicochemical properties and biological activities are summarized. The recent advances of SPH in cancer therapy as carriers, prodrugs, or drugs are highlighted. Finally, the clinical translation potential and main challenges in this field are also discussed.

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“…Tandem peptide-based nanoparticles have shown improved delivery of siRNAs to the site of injury and target the injured neuron upon systemic circulation. In this, nanoparticles have shown its own identify in delivering the peptides through brain targeting 22 . Some of the examples are listed in Table 1.…”

Section: Brain Targeted Ddsmentioning

confidence: 99%

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2021

IJPSR

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Drug Delivery with Designed Peptide Assemblies

Cited by 96 publications

References 134 publications

Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy

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