Drug Development and Analysis Review

Haque, Sk Manirul; Ratemi, Elaref

doi:10.1007/s11094-017-1543-1

Cited by 18 publications

(8 citation statements)

References 45 publications

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“…In the year 1980, HPLC was first time used for the assay of bulk drugs 3 . Further, this method became the main in USP XXVII and to a lesser extent, but widely used method in European Pharmacopoeia [6][7] .…”

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

“…1. 3 The selection of appropriate detecting method in HPLC play an important role as it has to detect all the components. UV detector is the most commonly used detector in HPLC; UV detector provides multiple wavelength scanning program, which facilitates monitoring several wavelengths simultaneously.…”

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

“…5 3 . Despite the various advantages of HPLC, it has its own limitations such as the cost of column is high, more solvent required, and lack of long term reproducibility due to propriety column packing 3 .…”

Section: Fig 4: Usage Of Various Detectors In Hplc Analysis Of Drugsmentioning

confidence: 99%

“…Hence this may lead to a change in the impurity profile of the APIs. Such changes may produce major consequences, including difficult interpretation of toxicological and clinical studies 3 . The presence of impurities in APIs can have a significant impact on the quality safety of the products.…”

Section: Introductionmentioning

confidence: 99%

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Untitled

2022

IJPSR

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Discovery of the drug molecule which has therapeutic values is the backbone of drug development. Pharmaceuticals have an important role in the prevention and treatment of diseases in humans and animals. However, gradual change in the process of drug synthesis from drug development to bulk production is a common complication in the drug development process. This change may result in the formation of impurities. Moreover, impurities can also be formed during transport and storage. The presence of more than the prescribed limit of impurities in the drugs may influence the purpose of the pharmaceuticals. Therefore, the evaluation of pharmaceutical drugs for the identification and quantification of impurities at various stages is essential. Several chemical and instrumental methods are used to assess the impurities. For this purpose, analytical instrumentations and methods play a crucial role. The current review highlights the development of impurities at various stages of drug development and pharmaceutical manufacturing. Moreover, this review put light on the recent advancement in the analysis of pharmaceuticals.

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Section: High-performance Liquid Chromatographymentioning

confidence: 99%

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

Section: Fig 4: Usage Of Various Detectors In Hplc Analysis Of Drugsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2022

IJPSR

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“…Furthermore, the main drawback of these methods for routine analysis is often due to their large generation of waste. Other analytical techniques have been described in the literature for pharmaceutical analyses of NTI drugs, including beyond chromatography, spectroscopic and titration methods . Electrochemical methods have also been used in the analysis of NTI drugs in pharmaceutical formulations .…”

Section: Introductionmentioning

confidence: 99%

Fast and Simple Electrochemical Analysis Kit for Quality Control of Narrow Therapeutic Index Drugs

Guedes

Santos

2018

Electroanalysis

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The use of multiple‐pulse amperometry (MPA) for the determination of narrow therapeutic index (NTI) drugs using batch injection analysis (BIA) with carbon screen‐printed electrodes (SPE) is proposed, seeking to develop a practical and low‐cost analysis kit for application in routine quality control of these drugs. The electrochemical behaviors of aminophylline, carbamazepine, clindamycin, colchicine, minoxidil, prazosin, procainamide, theophylline, warfarin and verapamil were evaluated in different electrolytes, but just one, the 0.1 mol L−1 phosphate buffer, pH 7.0, was chosen for determination of all the analytes. The amperometric detection was optimized as a function of the best oxidation potential for carbon SPE for each analyte, which was in a range from 0.7 to 1.1 V. The injection conditions were determined as a function of the velocity and the volume injected by the BIA system, which were 92.5 μL s−1 and 100 μL, respectively. Under these conditions, a good repeatability (RSD<3 %), high analytical frequency (>215 determinations per hour), large linear ranges and low LOD (<0.42 μmol L−1) for all the NTI drugs were obtained. Furthermore, the proposed method provided an easy qualitative analysis of the investigated analytes using MPA detection. The addition‐recovery studies in pharmaceutical samples containing NTI drugs and the comparison with official methods showed that the proposed analysis Kit is a very fast, simple and efficient alternative for quantification of these analytes.

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Nanocarriers for Skin Applications: Where Do We Stand?

et al. 2021

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Skin penetration of active molecules for treatment of diverse diseases is a major field of research owing to the advantages associated with the skin like easy accessibility, reduced systemic‐derived side effects, and increased therapeutic efficacy. Despite these advantages, dermal drug delivery is generally challenging due to the low skin permeability of therapeutics. Although various methods have been developed to improve skin penetration and permeation of therapeutics, they are usually aggressive and could lead to irreversible damage to the stratum corneum. Nanosized carrier systems represent an alternative approach for current technologies, with minimal damage to the natural barrier function of skin. In this Review, the use of nanoparticles to deliver drug molecules, genetic material, and vaccines into the skin is discussed. In addition, nanotoxicology studies and the recent clinical development of nanoparticles are highlighted to shed light on their potential to undergo market translation.

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Drug Development and Analysis Review

Cited by 18 publications

References 45 publications

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Fast and Simple Electrochemical Analysis Kit for Quality Control of Narrow Therapeutic Index Drugs

Nanocarriers for Skin Applications: Where Do We Stand?

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