Drug Discovery and Development for Human African Trypanosomiasis

Spaulding, Andrew; Gallerstein, Mitchell F.; Ferrins, Lori

doi:10.1002/9783527808656.ch5

Cited by 4 publications

(3 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first two are detected in West/Central Africa and East Africa, respectively, while the last is rarely spotted with the population of these regions. The parasite is transmitted to humans and domestic animals through the bite of infected tsetse flies and causes the endemic HAT disease [ 21 ].…”

Section: Kinetoplastid Parasites and Related Diseasesmentioning

confidence: 99%

“…Nifurtimox generates nitro radical anions and becomes reactive in the presence of oxygen [ 19 ]. Nifurtimox is no longer used as a therapeutical agent of CD in Brazil due to the fact that it causes neurological disorders or psychiatric episodes as side effects [ 20 , 21 ]. Many patients find out that they have contracted of Chagas disease years after the infection.…”

Section: Current Regimen For Kinetoplastid Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

An Overview on Target-Based Drug Design against Kinetoplastid Protozoan Infections: Human African Trypanosomiasis, Chagas Disease and Leishmaniases

et al. 2021

View full text Add to dashboard Cite

The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and leishmaniases span worldwide and therefore their impact is a universal concern. The present regimen against kinetoplastid protozoan infections is poor and insufficient. Target-based design expands the horizon of drug design and development and offers novel chemical entities and potential drug candidates to the therapeutic arsenal against the aforementioned neglected diseases. In this review, we report the most promising targets of the main kinetoplastid parasites, as well as their corresponding inhibitors. This overview is part of the Special Issue, entitled “Advances of Medicinal Chemistry against Kinetoplastid Protozoa (Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.) Infections: Drug Design, Synthesis and Pharmacology”.

show abstract

Section: Kinetoplastid Parasites and Related Diseasesmentioning

confidence: 99%

Section: Current Regimen For Kinetoplastid Diseasesmentioning

confidence: 99%

An Overview on Target-Based Drug Design against Kinetoplastid Protozoan Infections: Human African Trypanosomiasis, Chagas Disease and Leishmaniases

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Fexinidazole (FEX) seems to be a 2-substituted 5nitroimidazole with antimicrobial activities group, in particular, T. B. Rhodesiense and T. B. Gambian, such as In vitro and In vivo. Clinical development research on absorption, distribution, metabolism, and elimination of Fexinidazole proves that it would be highly consumed but quickly dispersed throughout the tissue, including that of the brain [7,8]. Because even though FEX, like several other nitroheterocycles, does seem to be mutagenic inside the Ames assess, that's not genetically dangerous complete mammalian cells such as in vitro or in vivo, does as well hardly portray one genotoxic danger to humans [9,10].…”

Section: Introductionmentioning

confidence: 99%