Drug eluting titanium implants for localised drug delivery

Singh, Maninder; Gill, Amoljit Singh; Deol, Parneet Kaur; Agrawal, Anupam; Sidhu, Sarabjeet Singh

doi:10.1557/s43578-022-00609-y

Cited by 11 publications

(5 citation statements)

References 105 publications

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“…Drug therapy is an important means to improve osteogenesis and reduce inflammation. Local drug delivery has a number of distinct advantages over systemic administration in implant therapy [168]. This method avoids the harsh gastrointestinal environment [169], provides a higher concentration of the drug at the implant site [170], reduces side effects at other sites [171], and allows targeted treatment.…”

Section: The Release Of Bioactive Substancesmentioning

confidence: 99%

Effects of surface morphology and composition of titanium implants on osteogenesis and inflammatory responses: a review

Wan

Wang

et al. 2023

Biomed. Mater.

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Titanium and its alloys have been widely used in bone tissue defect treatment owing to their excellent comprehensive properties. However, because of the biological inertness of the surface, it is difficult to achieve satisfactory osseointegration with the surrounding bone tissue when implanted into the body. Meanwhile, an inflammatory response is inevitable, which leads to implantation failure. Therefore, solving these two problems has become a new research hotspot. In current studies, various surface modification methods were proposed to meet the clinical needs. Yet, these methods have not been classified as a system to guide the follow-up research. These methods are demanded to be summarized, analyzed, and compared. In this manuscript, the effect of physical signal regulation (multi-scale composite structure) and chemical signal regulation (bioactive substance) generated by surface modification in promoting osteogenesis and reducing inflammatory responses was generalized and discussed. Finally, from the perspective of material preparation and biocompatibility experiments, the development trend of surface modification in promoting titanium implant surface osteogenesis and anti-inflammatory research was proposed.

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Section: The Release Of Bioactive Substancesmentioning

confidence: 99%

Effects of surface morphology and composition of titanium implants on osteogenesis and inflammatory responses: a review

Wan

Wang

et al. 2023

Biomed. Mater.

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“…Active biopolymers such as poly ( l -lactic acid) (PLLA) [ 8 ], polyglycolic acid (PGA) [ 9 ], collagen [ [10] , [11] , [12] ], and ceramics (hydroxyapatite (HA) [ 13 ] as well as tricalcium phosphate [ 14 , 15 ] and bioglasses [ 16 ] have demonstrated favorable outcomes in terms of bone or tissue growth. However, these materials are deprived of suitable mechanical properties due to their brittleness and low fracture strength [ 17 ]. In this regard, metallic materials, biologically neutral in response with excellent mechanical performance, are considered the most suitable materials [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Advancements in materials science and manufacturing technologies have significantly improved the success rate of implantation to approximately 90%. Nevertheless, premature implant failures due to improper bone integration with the implant, the body's immune response to foreign intrusion, and bacterial infections still necessitate further interventions [ 17 ]. Clinical reports indicate a failure rate of over 10% in the clinical application of bone implants, with 18% attributed to implant loosening and 20% to bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

“…Another method, Local Drug Delivery (LDD), has found widespread application in orthopedics and dentistry. LDD offers several advantages over systemic drug delivery in implant-based treatments: Versatility in Drug Delivery, Optimal Drug Concentration, Personalized Treatment and Effectiveness due to Proximity [ 17 , [24] , [25] , [26] , [27] , [28] ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of bioactivity and antibacterial properties of Ti6Al4V-based green biocomposite implant encompassing TiO2 nanotube arrays and garlic extract

Jebeli,

Aghdam,

Najjari

et al. 2024

Heliyon

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“…In this conceptual framework, the integration of local drug delivery (LDD), namely the release of active compounds at the body site of interest, features that prevent infections and/or promote osteointegration and bone regeneration can reduce the risk of post-operative complications and increase the success rates. LDD is more advantageous than systemic drug administration because it reduces the effective drug dose, ensures maximum bioavailability in a tissue with more limited blood supply and minimizes associated systemic side-effects [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Drug-eluting biodegradable metals and metal-ceramic composites: High strength and delayed drug release

Sharipova

Бакина

Ложкомоев

et al. 2022

Preprint

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Biodegradable metals emerged as promising temporary bone implants. The integration of additional features such as local drug delivery (LDD) can also support their osteointegration, promote bone regeneration, and prevent biomaterial-centered infections that are difficult to treat. LDD is achieved by drug-eluting coatings or porous implants where the drug is impregnated after implant fabrication because the high temperatures used during conventional production processes would result in their thermal decomposition. We produced biodegradable iron (Fe)-based vancomycin (VH)-eluting metals and metal-ceramic composites by a simple high-pressure consolidation/cold sintering (CS) process at room temperature that display high mechanical strength and antibacterial activity. Aiming to expand the application of this production method and shed light into the drug loading and release mechanisms in this type of biomaterials, this work reports on the production and characterization of VH-loaded Fe and Fe-iron oxide (Fe2O3) composites (Fe-Fe2O3). We use focus ion beam milling for the first time to investigate the drug-metal interface and investigate the mechanical and degradation properties of VH-free and VH-loaded Fe and Fe-Fe2O3. Results show very high mechanical strength of drug-eluting Fe and Fe-Fe2O3 composites (up to than 780 MPa under compression, exceeding the maximum strength of cancellous bone more than three times) accompanied by a delayed drug release. Then, we confirm the good antimicrobial activity against Staphylococcus aureus and cell compatibility with the murine embryonic fibroblast cell line NIH/3T3 in vitro. Overall results confirm the promise of drug-eluting metals and metal-ceramic composites for LDD in bone.

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Drug eluting titanium implants for localised drug delivery

Cited by 11 publications

References 105 publications

Effects of surface morphology and composition of titanium implants on osteogenesis and inflammatory responses: a review

Effects of surface morphology and composition of titanium implants on osteogenesis and inflammatory responses: a review

Evaluation of bioactivity and antibacterial properties of Ti6Al4V-based green biocomposite implant encompassing TiO2 nanotube arrays and garlic extract

Drug-eluting biodegradable metals and metal-ceramic composites: High strength and delayed drug release

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