Drug free anti-cell proliferative and anti-platelet adhesion coating for vascular stents via polymeric electrospun fibers

Chalony, Carmen; Aguilar, Ludwig Erik; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.matlet.2021.129545

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…However, the incidence of restenosis after implantation reaches nearly 34%, and restenosis has become the main factor restricting the development of PTCA [2][3][4]. The preparation of the drug coating on the stent surface inhibits the transition proliferation of smooth muscle cells through drug sustained release, which has become an effective method for the treatment of restenosis [5][6][7][8]. Poly lactic-co-glycolic acid (PLGA) has shown broad applicability as a drug carrier because of its reliable safety, excellent biocompatibility, and controllable biodegradability.…”

Section: Introductionmentioning

confidence: 99%

PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility

Jia

Zhang

2021

Coatings

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PLGA (Poly lactic-co-glycolic acid) and PLGA drug-loading coatings were prepared on 316 L stainless steel by electrostatic spray deposition (ESD). The surface morphology, three-dimensional morphology, and crystal structures of the coatings were observed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray diffraction (XRD). Thermal properties, molecular weight, and coating composition were studied by differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and NMR. The degradation behaviors of the coatings were studied by mass changes, relative molecular mass and distributions, polymer compositions, thermal properties, and surface morphologies. The blood compatibilities of the coatings were investigated by platelet adhesion testing and dynamic coagulation times. SEM results indicated the drug-loading coating with 33% RAPA had the smoothest and most compact morphology. Addition of RAPA decreased the Tg of the PLGA coating, accompanied by partial crystallization that slowed the degradation rate of the drug-loaded coating. Microscopically, the morphology of the PLGA drug-loaded coating was coarser than the PLGA coating. The average surface roughness values of line and surface scannings were 16.232 nm and 39.538 nm, respectively. The surface of the drug-loading coating was micro uneven, and the macro smooth and micro multiphase separation structure helped improve its blood compatibility.

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